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The Korean Journal of Pathology 1999;33(7): 507-516.
DNA Ploidy Analysis as a Prognostic Indicator in Phyllodes Tumor of the Breast.
Hee Jung Kim, Jae Ho Han, Woo Hee Jung, Hy De Lee
1Department of Pathology, Yonsei University College of Medicine, Seoul 135-720, Korea.
2Department of General Surgery, Yonsei University College of Medicine, Seoul 135-720, Korea.
ABSTRACT
DNA ploidy analysis using flow cytometry was performed on sixty six cases of phyllodes tumor of the breast including benign, low grade and high grade malignant phyllodes tumor. The rate of aneuploidy was 41.2% in high grade malignant phyllodes tumor and 4.8% in benign phyllodes tumor. No aneuploidy was noted in low grade malignant phyllodes tumor. The recurrence rate according to DNA ploidy pattern revealed 16.7% of aneuploidy and 7.7% of diploidy. In the aneuploid cases, the DNA index of high grade malignant phyllodes tumor was higher than benign phyllodes tumor. Morever, in diploid cases, %SG2M were significantly higher in high grade malignant phyllodes tumor. Therefore, we conclude that DNA ploidy analysis as well as histologic characteristics such as cellularity, pleomorphism of stromal cells and mitoses is useful parameters in the diagnosis, recurrence and prognostic predictors of phyllodes tumor.
Key Words: Breast; Neoplasm; Phyllodes tumor; DNA ploidy; Flow cytometry; Prognosis