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The Korean Journal of Pathology 1999;33(4): 288-291.
Herpes Simplex Esophagitis: A report of two cases.
Eun Ha Jung, Hae Kyung Ahn, Jin Hee Sohn
Department of Pathology, College of Medicine, Hallym University, Seoul 150-020, Korea.
Herpes simplex esophagitis has been recognized with increased frequency as an opportunistic infection in immunosuppressed or debilitated patients. However, it is also documented as self-limited esophagitis in apparently healthy patients. We report two cases of herpetic esophagitis diagnosed by biopsies. One case was noted in an immunocompetent patient having gastric peptic ulcer who had clinical improvement with symptomatic treatment. And the other was noted in an immunosuppressed patient having chemotherapy for gastric carcinoma who had resolution of symptoms with acyclovir therapy. Histologically, esophageal mucosa exhibited erosion and inflammatory cellular exudate with intranuclear eosinophilic inclusions in the epithelial cells. These were confirmed by the PCR and immunohistochemical stain for herpes simplex virus using a biopsy material.
Key Words: Herpes simplex virus; Esophagitis