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The Korean Journal of Pathology 1999;33(2): 145-148.
B-cell Prolymphocytic Leukemia Involving Entire Female Genital Tract: A case report.
Hee Jung Lee, Young Shin Kim, Yong Gu Kim, Kyung Ja Han, Kyo Young Lee, Chang Suk Kang, Sang In Shim, Jong Wook Lee, Woong Shick Ahn, Soo Pyung Aim, Seung Il Kim
1Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul 150-713, Korea.
2Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 150-713, Korea.
3Department of Obstetrics & Gynecology, College of Medicine, The Catholic University of Korea, Seoul 150-713, Korea.
4Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 150-713, Korea.
ABSTRACT
Prolymphocytic leukemia is a chronic lymphoproliferative disorder, characterized by prominent splenomegaly, prolymphocytes accounting for more than 55% of circulating lymphocytes, no significant peripheral lymphadenopathy and short term survival with terminal fatal multi-organ failure. We report a case of B-cell prolymphocytic leukemia in a 57-year-old woman who presented with easy bruising and arthritis for 1 year and low abdominal pain for 2 months. Physical examination revealed gingival hypertrophy and mild splenomegaly. On peripheral blood smears the leukocytes were markedly increased in number due to leukemic cells that count about 62% of leukocytes. The bone marrow aspiration smear and biopsy revealed diffuse infiltration of medium to large prolymphocytes having moderate amount of basophilic cytoplasm, round to oval nuclei with coarse chromatin, and prominent nucleoli. Abdominal pain aggravated despite chemotherapy, and pelvic computed tomography (CT) revealed a huge lobular pelvic mass which had increased in size on the follow-up CT. Total hysterectomy with bilateral adnexectomy was performed. Microscopic findings included massive infiltration of prolymphocytic cells in the uterus, upper vaginal wall, bilateral ovaries, and bilateral mesosalpinges. On immunohistochemistry, the leukemic cells showed B cell gamma light chain phenotype.
Key Words: B-prolymphocytic leukemia; Female genital tract