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The Korean Journal of Pathology 1999;33(1): 48-51.
Primary Malignant Fibrous Histiocytoma of the Liver: A case report.
Bum Kyeong Kim, Kyeong Hee Kim, Hye Jeong Sul, Dae Young Kang
Department of Pathology, College of Medicine, Chungnam University, Daechun 301-721, Korea.
Malignant fibrous histiocytoma (MFH) of the liver is uncommon, representing less than 1% of the primary malignant lesions of the liver. We report primary MFH of the liver in a 59-year-old woman. The tumor, measuring 9.0 9.0 6.0 cm, was located in the left lobe of the liver. It showed multiple areas of hemorrhage and necrosis. Microscopically, the tumor consisted of plump spindle cells haphazardly arranged in short fascicle and focal storiform pattern. Multiple bizarre giant cells were also noted. Immunohistochemically, many of the tumor cells were positive for vimentin and alpha1-antitrypsin but negative for epithelial markers. Ultrastructurally, the tumor cells showed fibroblastic and histiocytic features.
Key Words: Malignant fibrous histiocytoma (MFH); Liver; alpha1-antitrypsin; Vimentin; Electron microscopy