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The Korean Journal of Pathology 1998;32(5): 378-381.
Sarcomatoid Renal Cell Carcinoma; Special Reference to its Distinction from Carcinosarcoma.
Kee Taek Jang, Yeon Mee Kim, Je Geun Chi
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
ABSTRACT
Sarcomatoid renal cell carcinoma is an uncommon tumor that has to be distinguished from renal carcinosarcoma. We have described three cases of sarcomatoid renal cell carcinoma showing different clinical and light microscopic features. An ultrastructural study of the tumor cells from the sarcomatoid area revealed frequent desmosomal junction, confirming the epithelial nature of the neoplasm. All three cases showed an aggressive clinical course and tended to invade adjacent organs or tissues. We believe that an histological and immunohistochemical examination in conjunction with an electron microscopic examination are necessary to diagnose sarcomatoid renal cell carcinoma.
Key Words: Sarcomatoid renal cell carcinoma; Carcinosarcoma; Desmosome; Electron microscopy