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The Korean Journal of Pathology 1998;32(3): 226-230.
Hyalinizing Trabecular Adenoma of the Thyroid: A case report.
Hyun ee Yim, Chull Shim, Euy Young Soh
1Department of Pathology, Ajou University School of Medicine, Suwon, Korea.
2Department of General Surgery, Ajou University School of Medicine, Suwon, Korea.
We report a case of hyalinizing trabecular adenoma of the thyroid gland with its immunohistochemical and ultrastructural features. A 53 year-old euthyroid woman presented a well defined small cold nodule on a thyroid iodine scan. Microscopically, oval and elongated tumor cells were arranged in trabeculae, clusters and a "zellballen" pattern resembling paraganglioma with scattered follicles. Nuclear features were characterized by fine nuclear grooves, acidophilic intranuclear cytoplasmic inclusions and perinucleolar halos. Abundant extracellular eosinophilic fibrohyaline matrix resembling amyloid were also noted. Immunostaining of tumor cells was positive for thyroglobulin and negative for calcitonin. In addition, tumor cells displayed an unexpected, unique cytoplasmic immunoreactivity for MIB1. Electron microscopy revealed euchromatic nuclei with grooves, intranuclear cytoplasmic inclusions, intermediate filament stuffed cytoplasms and abundant extracellular basal lamina material.
Key Words: Hyalinizing trabecular adenoma; Thyroid gland; Paraganglioma-like adenoma