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JPTM > Ahead-of Print

doi: https://doi.org/10.4132/jptm.2019.08.05    [Epub ahead of print]
Concurrent Anti-glomerular Basement Membrane Nephritis and IgA Nephropathy
Kwang-Sun Suh1 , Song-Yi Choi1 , Go Eun Bae1 , Dae Eun Choi2 , Min-kyung Yeo1
1Department of Pathology, Chungnam National University School of Medicine, Daejeon, Republic of Korea
2Department of Nephrology, Chungnam National University School of Medicine, Daejeon, Republic of Korea
Corresponding Author: Min-kyung Yeo ,Tel: 82-42-280-7196, Fax: 82-42-280-8199, Email: mkyeo83@gmail.com
Received: June 11, 2019;  Revised: July 31, 2019  Accepted: August 5, 2019.  Published online: September 16, 2019.
ABSTRACT
Anti-glomerular basement membrane (GBM) nephritis is characterized by circulating anti-GBM antibodies and crescentic glomerulonephritis (GN) with deposition of immunoglobulin (Ig) G along the GBM. In a limited number of cases, glomerular immune complexes have been identified in anti-GBM nephritis. A 38-year-old female presented azotemia, hematuria, and proteinuria without any pulmonary symptoms. A renal biopsy showed crescentic GN with linear IgG deposition along the GBM and mesangial IgA deposition. The patient was diagnosed as concurrent anti-GBM nephritis and IgA nephropathy. Therapies with pulse methylprednisolone and cyclophosphamide administration were effective. Concurrent cases of both anti-GBM nephritis and IgA nephropathy are rare among cases of anti-GBM diseases with deposition of immune complexes. This rare case of concurrent anti-GBM nephritis and IgA nephropathy with literature review is noteworthy.
Key Words: Anti-glomerular basement membrane, Immunoglobulin A, Crescentic glomerulonephritis Introduction