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JPTM > Ahead-of Print

doi: https://doi.org/10.4132/jptm.2019.03.21    [Epub ahead of print]
Serous Adenocarcinoma of Fallopian Tubes: Histological and Immunohistochemical Aspects
Natalia Hyriavenko1, Mykola Lуndіn1, Kateryna Sikora2, Artem Piddubnyi1, Ludmila Karpenko1, Olha Kravtsova2, Dmytrii Hyriavenko3, Olena Diachenko3, Vladyslav Sikora1, Anatolii Romaniuk1
1Department of Pathology, Sumy State University, Sumy, Ukraine
2Department of Pathology, Sumy Regional Clinical Perinatal Center, Sumy, Ukraine
3Department of Pathology, Sumy State University, Sumy, Ukraine
Corresponding Author: Natalia Hyriavenko ,Tel: +380997466578, Email: n.gyryavenko@med.sumdu.edu.ua
Received: January 16, 2019;  Revised: March 15, 2019  Accepted: March 20, 2019.  Published online: April 11, 2019.
ABSTRACT

Background:
Although primary cancer of the fallopian tubes is a relatively rare type of tumor in female reproductive organs, its mortality is quite high. It is important to identify molecular and biological markers of this malignancy that determine its specific phenotype.
Methods:
The study was carried out on samples received from 71 female patients with primary cancer of the fallopian tubes. The main molecular and biological properties, including hormone status (ER, PR), HER2/neu expression, proliferative potential (Ki-67), apoptosis (p53, bcl-2), and pro-angiogenic (VEGF) quality of serous tumors were studied in comparison with clinical and morphological characteristics.
Results:
ER and PR expression is accompanied by low grade neoplasia, early clinical disease stage, and absence of lymphogenic metastasis (р<0.001). HER2/neu expression is not typical for primary cancer of the fallopian tubes. Ki-67 expression is characterized by an inverse correlation with ER and PR (р<0.05) and is associated with lymphogenic metastasis (р<0.01). P53+ status correlates with high grade malignancy, tumor progression, metastasis, negative ER/PR (р<0.001), and negative bcl-2 status (р<0.05). Positive bcl-2 status is positively correlated with ER and PR expression and, low grade malignancy.
Conclusions:
Complex morphologic (histological and immunohistochemical) study of postoperative material allows estimation of the degree of malignancy and tumor spread to enable appropriate treatment for each case.
Key Words: Serous carcinoma; Tumor; Fallopian tubes; ER; PR; Ki-67; HER2/neu