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JPTM > Volume 53(1); 2019 > Article
Journal of Pathology and Translational Medicine 2019;53(1): 70-74.
doi: https://doi.org/10.4132/jptm.2018.11.09
Cytopathologic Features of Secretory Carcinoma of Salivary Gland: Report of Two Cases
Young Ah Kim , Jae Won Joung , Sun-Jae Lee , Hoon-Kyu Oh , Chang Ho Cho , Woo Jung Sung
Department of Pathology, Catholic University of Daegu School of Medicine, Daegu, Korea
Corresponding Author: Woo Jung Sung ,Tel: +82-53-650-4159, Fax: +82-53-650-3456, Email: wjsung@cu.ac.kr
Received: October 31, 2018;  Revised: November 8, 2018  Accepted: November 9, 2018.  Published online: December 28, 2018.
Secretory carcinoma of the salivary gland (SC) is a newly introduced rare salivary gland tumor that shares histological, immunohistochemical, and genetic characteristics with secretory carcinoma of the breast. Here, we report the cytologic features of two cases of SC confirmed by surgical resection. In these two cases, SC was incidentally detected in a 64-year-old female and a 56-yearold male. Fine needle aspiration cytology revealed nests of tumor cells with a papillary or glandular structure floating in mucinous secretions. The tumor cells demonstrated uniform, round, smooth nuclear contours and distinct nucleoli. Multiple characteristic cytoplasmic vacuoles were revealed. Singly scattered tumor cells frequently showed variable sized cytoplasmic vacuoles. The cytopathologic diagnosis of SC should be considered when characteristic cytological findings are revealed. Further immunohistochemistry and gene analyses are helpful to diagnose SC.
Key Words: Secretory carcinoma; Mammary analogue secretory carcinoma; Salivary gland; Cytology