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JPTM > Volume 53(2); 2019 > Article
Kim, Shim, and Kim: Wharton Jelly Hair in a Case of Umbilical Cord Stricture and Fetal Death
Placenta forms the intrauterine environment that supplies oxygen and nutrients to the fetus during pregnancy. The umbilical cord is the lifeline of the fetus that connects the fetus to the placenta. An abnormally thin umbilical cord is associated with adverse pregnancy outcomes such as oligohydramnios, fetal growth restriction, and fetal distress [1,2]. Critical events occurring in the umbilical cord, especially stricture, knots, hemorrhage, and strangulation, often lead to fetal death [3,4]. Here, we report for the first time an autopsy case of fetal death caused by umbilical cord stricture accompanied by hair growth in the Wharton jelly.

CASE REPORT

A 28-year-old primigravida woman presented with severe fetal growth restriction and oligohydramnios at 23 weeks of gestational age. Five days later, the ultrasound examination revealed fetal death in utero, and a macerated female fetus weighing 350 g (< 3rd percentile) was delivered [5]. The circumference of the head was 18.0 cm (< 3rd percentile) [6], and that of the abdomen was 14.4 cm (< 3rd percentile) [6]. Infantogram showed mildly hypoplastic thoracic cage (Fig. 1A), and chest circumference was 14.6 cm (10th–25th percentile) [7]. Chromosomal analysis by amniocentesis performed at 18 weeks showed normal findings.
Fetal autopsy and placental biopsy revealed hypocoiling of the umbilical cord (Fig. 1B) with a rather abrupt stricture located 6.5 cm from the placental insertion. Localized edema of the umbilical cord was associated with the stricture. The diameter of the umbilical cord at the stricture was 4 mm, which was lower than the 10th percentile of the normal range (Fig. 2) [1]. Microscopic examination of the umbilical cord stricture revealed hair follicles including hair shafts and papillary mesenchymal body in the firm and fibrotic Wharton jelly. Capillary vessel formation was also found in the peripheral region of the Wharton jelly (Fig. 3). Squames were detected in the alveoli of fetal lungs, and chorionic villi showed increased syncytial knots and distal villous hypoplasia. Overall, the umbilical cord stricture associated with unusual development of hair follicles and fibrotic Wharton jelly seems to have significantly contributed to the fetal demise.
The mother has provided written informed consent for autopsy prior to the postmortem examinations. Since only the pathology and autopsy findings of an already deceased fetus and only deidentified personal information of the mother and the fetus were used, the Institutional Review Board (IRB) of Asan Medical Center determined exemption (IRB number: 2017-1192).

DISCUSSION

The Wharton jelly is the umbilical cord stroma that originates from the extraembryonic mesoderm of allantois. The Wharton jelly is rich in mucopolysaccharides such as hyaluronic acid and chondroitin sulfate and thus protects umbilical vessels from compression [8]. Loss of protection by the Wharton jelly can lead to compromised fetoplacental circulation and subsequent fetal death [9]. Umbilical cord stricture is a known cause of fetal death [3]. Hypocoiling also renders umbilical cord vessels susceptible to kinking and acute obstruction.
The Wharton jelly has been extensively studied as a reservoir of mesenchymal stem cells (MSCs) in the field of regenerative medicine. The Wharton jelly MSCs show a differentiation spectrum covering ectodermal and endodermal lineages [10]. To the best of our knowledge, the current case is the first example of hair growth and follicle formation in the umbilical cord. It should also be mentioned that hair formation overlaps with a fibrotic change in the Wharton jelly and the development of capillaries. Capillaries are not normally observed in the Wharton jelly, and the anatomical location of the stricture is apart from the umbilicus, where fetal skin tissue can coexist. It is unclear at this point whether the hair and capillaries are products of de novo differentiation of pluripotent Wharton jelly MSCs. The development of multiple capillaries in the periphery and fibrosis of Wharton jelly may be secondary consequences of stricture, and the capillaries can be considered collaterals for compensating for chronically compromised umbilical circulation.
In addition to developmental uniqueness, lessons from the current case include that thorough histologic examination is necessary to determine the cause of fetal death and document significant findings.

Notes

Author contributions

Conceptualization: CJK.

Data curation: ENK.

Investigation: ENK.

Methodology: ENK.

Resources: JYS.

Supervision: CJK.

Visualization: CJK.

Writing—original draft: ENK.

Writing—review & editing: CJK, JYS.

Conflicts of Interest

The authors declare that they have no potential conflicts of interest.

Fig. 1.
Major characteristics of the fetus. (A) Infantogram shows hypoplastic small rib cage (arrow). (B) The stillborn macerated fetus has no coiling of the umbilical cord (arrow).
jptm-2018-10-24f1.jpg
Fig. 2.
Gross features of the placenta and the umbilical cord. (A) The umbilical cord is marginally inserted, and the connecting chorionic plate vasculature is tortuous and prominent (red arrow). The umbilical cord shows abrupt constriction (white arrow) and associated segmental edema of the Wharton jelly (yellow arrow). (B) A view from the maternal side of the placenta shows a constriction in the umbilical cord (white arrow). The placental parenchyma is pale and edematous (red arrow).
jptm-2018-10-24f2.jpg
Fig. 3.
Microscopic features of the umbilical cord at the stricture. (A) Dense fibrosis of the Wharton jelly at the site of constriction (right) and adjacent edematous Wharton jelly (left). (B) Multiple hair follicles (yellow arrows) and capillaries (red arrows). (C, D) Hair shafts (black arrows) with adjacent papillary mesenchymal body of the hair follicles (yellow arrows) and capillaries (red arrows).
jptm-2018-10-24f3.jpg

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