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The Korean Journal of Pathology 1998;32(2): 150-152.
Epstein-Barr Virus Associated Lymphoepithelial Carcinoma of the Parotid Gland: A case report.
Kwang Il Kim, Young Sik Kim, In Sun Kim
Department of Pathology, College of Medicine, Korea University, Seoul, Korea.
Lymphoepithelial carcinoma is a rare subtype of undifferentiated carcinoma in the salivary gland. The incidence of lymphoepithelial carcinoma is about 0.4% among the patients with major salivary gland tumors. It has a racial preference; about 75% of the patients are of Mongolian ancestry. We report a case of lymphoepithelial carcinoma arising in the left parotid gland of a 52-year-old man. Grossly, the tumor was relatively well demarcated, gray-white, and solid. Microscopically, the irregular shaped syncytial tumor cell islands were evident within lymphoplasma cell-rich and desmoplastic stroma. The carcinoma cells had large vesicular nuclei and prominent nucleoli. The tumor invaded the surrounding salivary gland tissue. Epstein-Barr virus (EBV) was demonstrated by in situ hybridization for EBV-encoded RNA-1 (EBER-1) and polymerase chain reaction for EBV nuclear antigen-1 (EBNA-1).
Key Words: Lymphoepithelial carcinoma; Salivary gland; Epstein-Barr virus