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JPTM > Ahead-of Print

doi: https://doi.org/10.4132/jptm.2018.09.13    [Epub ahead of print]
The Expression of Adipophilin Is Frequently Found in Solid Subtype Adenocarcinoma and Is Associated with Adverse Outcomes in Lung Adenocarcinoma
Sun Ah Shin1, Hee Young Na2, ‧ Ji Young Choe3, Doohyun Chung1, Mira Park4, Sohee Oh5, Ji Eun Kim4
1Department of pathology, Seoul National University Hospital, Seoul, Korea
2Department of pathology, Seoul National University Bundang Hospital, Seongnam, Korea
3Department of pathology, Hallym University Sacred Heart Hospital, Anyang, Korea
4Department of Pathology, Seoul National University Boramae Hospital, Seoul, Korea
5Department of Biostatics, Seoul National University Boramae Hospital, Seoul, Korea
Corresponding Author: Ji Eun Kim ,Tel: +82-2-870-2642, Fax: +82-2-831-0261, Email: npol181@snu.ac.kr
Received: August 7, 2018;  Revised: September 5, 2018  Accepted: September 13, 2018.  Published online: October 4, 2018.

The up-regulation of the lipogenic pathway has been reported in many types of malignant tumors. However, its pathogenic role or clinical significance is not fully understood. The objective of this study was to examine the expression levels of adipophilin and related hypoxic signaling proteins and to determine their prognostic impacts and associations with the pathologic characteristics of lung adenocarcinoma.
Expression levels of adipophilin, HSP27, CAIX, and HIF1α were examined by immunohistochemical staining using tissue microarray blocks. Correlations between protein expression levels and various clinicopathologic features were analyzed.
A total of 230 cases of primary adenocarcinoma of the lung were enrolled in this study. Adipophilin expression was more frequent in males and with the solid histologic type. It was correlated with HSP27 expression. Patients with adipophilin-positive adenocarcinoma showed a shorter progression free survival (PFS) (median PFS: 17.2 vs. 18.4 months) in a univariable survival analysis, whereas HSP27 positivity correlated with favorable overall survival (OS) and PFS. In a multivariable analysis, adipophilin and HSP27 were independent prognostic markers of both OS and PFS.
Activated lipid metabolism and the hypoxic signaling pathway might play a major role in the progression of lung adenocarcinoma, especially in the solid histologic type.
Key Words: Adipophilin; Lung adenocarcinoma; Hypoxia; Prognosis