| Home | E-Submission | Sitemap | Contact Us |  
JPTM > Volume 53(1); 2019 > Article
Journal of Pathology and Translational Medicine 2019;53(1): 57-61.
doi: https://doi.org/10.4132/jptm.2018.08.21
Primary Peripheral Gamma Delta T-Cell Lymphoma of the Central Nervous System: Report of a Case Involving the Intramedullary Spinal Cord and Presenting with Myelopathy
Jeemin Yim1 , Seung Geun Song1 , Sehui Kim1 , Jae Won Choi2 , Kyu-Chong Lee3 , Jeong Mo Bae1 , Yoon Kyung Jeon1
1Department of Pathology, Seoul National University Hospital, Seoul, Korea
2Department of Radiology, Seoul National University Hospital, Seoul, Korea
3Department of Radiology, Korea University Guro Hospital, Seoul, Korea
Corresponding Author: Yoon Kyung Jeon ,Tel: +82-2-740-8323, Fax: +82-2-743-5530, Email: ykjeon@snu.ac.kr
Received: July 23, 2018;  Revised: August 20, 2018  Accepted: August 21, 2018.  Published online: October 1, 2018.
Primary central nervous system lymphoma of T-cell origin (T-PCNSL) is rare, and its clinicopathological features remain unclear. Peripheral T-cell lymphoma of γδ T-cell origin is an aggressive lymphoma mainly involving extranodal sites. Here, we report a case of γδ T-PCNSL involving the intramedullary spinal cord and presenting with paraplegia. A 75-year-old Korean woman visited the hospital complaining of back pain and lower extremity weakness. Magnetic resonance imaging revealed multifocal enhancing intramedullary nodular lesions in the thoracic and lumbar spinal cord. An enhancing nodular lesion was observed in the periventricular white matter of the lateral ventricle in the brain. There were no other abnormalities in systemic organs or skin. Laminectomy and tumor removal were performed. The tumor consisted of monomorphic, medium-to-large atypical lymphocytes with pale-to-eosinophilic cytoplasm. Immunohistochemically, the tumor cells were CD3(+), TCRβF1(-), TCRγ(+), CD30(-), CD4(-), CD8(-), CD56(+), TIA1(+), granzyme B(+), and CD103(+). Epstein-Barr virus in situ was negative. This case represents a unique T-PCNSL of γδ T-cell origin involving the spinal cord.
Key Words: primary central nervous system lymphoma; primary intramedullary spinal cord lymphoma; peripheral T-cell lymphoma; γδ T-cell lymphoma
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
CrossRef TDM  CrossRef TDM
Supplement  Supplement
Related article