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The Korean Journal of Pathology 1984;18(1): 16-22.
Streptozotocin 투여가 백서 췌분비선의 미세구조에 미치는 영향
Ultrastructural Study on Streptozotocin -induced Pancreatic Acinar Injury in Rats
ABSTRACT
Experimental diabetes was produced in Sprague-Dawley rats by single dose of intraperitoneal injection of streptozotocin, 50㎎/kg and sacrificed on the 15th, 45th, and 90th day. Blood glucose levels were 400㎎/㎗ in all groups (normal control: 120㎎/㎗) and serum amylase level of a group after 45 days was 621.1 IU of average, whereas 750.5 IU in normal control group. The cytoplasms of pancreatic acinar cells were closely packed withh minute hydropic vacuoles and numerous fat globules, measuring 0.5~1.0μ in diameter. Electron microscopic findings represented mitochondrial swelling with loss of cristae and indistinct outlines. Populations of free ribosome were increased, but the zymogen granules were reduced than those of control group. The above findings support that streptozotocin induces acinar cell injury in part through the direct chemical toxicity on mitochondria.