Abstract

The term, "liver cell dysplasia", which was proposed and defined as cellular enlargement, nuclear pleomorphism, and multinucleation of liver cell occurring in groups or occupying whole cirrhotic nodule by Anthony et al, has been considered to be premalignant condition. The authors reviewed dysplasia in 247 cases with cirrhotic or cancerous livers including non-cirrhotic and nonmalignant control group, and studied the presence of HBsAg to evaluate the relationship between HBsAg and dysplasia in cirrhosis and hepatocellular carcinoma. The results are as follow: 1) Liver cell dysplasia was found in 6 out of 132 cases (4.5%) of control group, in 2 out of 16 cases (12.5%) with hepatocellular carcinoma, 28 of 89 cases (31.5%) with cirrhosis only, and 7 out of 10 cases (70%) with cirrhosis and hepatocellular carcinoma 2) There were no age and sex differences between cirrhosis and cirrhosis with hepatocellular carcinoma, with or without dysplasia. 3) Serum HBsAg were positive in 8 out of 12 cases (66.7%) with dysplasia, whereas positive in 5 our of 16 cases (31.2%) without dysplasia.