Abstract

An experimental model of gastric peptic ulcer by means of cell-mediated hypersensitivity induced with low dose gastric application of 2, 4-dinitrochlorobenzene(DNCB) in the previously sensitized New Zealand white rabbit is presented. Animals were divided into 4 groups; 2 non-sensitized animals with gastric application of DNCB(group I), 7 sensitized animals with gastric application of DNCB(group II and III), and 1 sensitized animal with colonic application of DNCB(group IV). In group I were only superficial and mild erosive changes of gastric mucosa, wherease in group II and III, 2 animals developed typical peptic ulcer in association with features of chronic gastritis and stereotypic area gastricae. The latter gastritic changes with early superficial peptic digestion were also demonstrable in the rests. No gastric mucosal changes were seen in group IV. It is assumed that type IV hypersensitivity reaction(Cell-mediated hypersensitivity) on gastric mucosa is responsible for the development of gastric ulcer and chronic gastritis, being useful as an experimental model of gastric ulcer. The applicability of this model to human stomach and reasons for the limited development of peptic ulcer were discussed.