The lactose ferementing Vibrio infection occurs mostly in man after his forties and concomitant chronic liver disease or other underlying disease can always be found. Secondary skin lesions are frequently accompanied and the causative organisms are usually isolated form either blood or extraintestinal lesional tissues. We here report 5 cases of L+Vibrio infection identified during the two year period from January, 1980 to December, 1981. The clinical, epidemiological and microbiological characteristics were as follows; 1) All patients showed positive blood culture results and in addition, one of them showed positive lesional skin culture results. 2) All patients were men and except one, were with their age over forties. The outbreak of the disease was during the summer season, i.e., August and September. 3) All patients had associated chronic liver disease or had the history of antecedent liver disease. Four patients showed skin lesions. Three patients died and their mean survival time after admission were 12 hours. While one patient died of chronic liver disease, the other one showed clinical improvement with antibiotic therapy. 4) The biochemical properties of the isolated oragnisms were consistent with other reports. Antibiotic susceptibility test of the isolated L+Vibrio showed resistance to cephalothin, lincomycin, methicillin, penicillin, gentamicin, and carbenicillin and sensitivity to chloramphenicol, tetracycline, kanamycin, ampicillin, and tobramycin.