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The Korean Journal of Pathology 1982;16(3): 367-375.
각종 간담도계 질환에 있어서 혈청 Cholylglycine의 임상적 이용에 관한 연구
An Evaluation of the Clinical Application of Serum Cholylglycine Measurement in Hepatobiliary Disease
ABSTRACT
There have been a number of so-called liver function tests in our routine clinical work, yet their capabilities are so limited that a new and more sensitive liver function test is highly desirable. Sherlock and Walshe (1948) were reported highly elevated serum bile acids in hepatobiliary diseases for the first time. Since then a number of investigators reported various conditions with elevated serum bile acids. Serum cholylglycine levels in 25 normal control subjects and 98 patients with abnormal liver function tests were determined by RIA method and the results were compared with conventional liver function tests. The following results were obtained. 1) The mean CG concentration in the fasting sera of normal control subjects was 10.7±8.9ug/㎗(mean±SD) and no difference was noted between male and female. 2) Significantly elevated serum CG levels were observed in 94 patients among of 98 patients with various hepatobiliary diseases. Among the hepatobiliary diseases the highest serum CG level was seen acute viral hepatitis. During the course of recovery from acute viral hepatitis, the decline of serum CG values was more rapid than other liver function test. 3) In the diagnosis of chronic persistent hepatitis, the serum CG test was less sensitive than AT, or ALT test, while it was more sensitive than the tests of ALP or total bilirubin. 4) Serum CG test was very sensitive in the diagnosis of chronic active hepatitis and cirrhosis. The test was considered valuable in the differential diagnosis of chronic active hepatitis from chronic persistent hepatitis. 5) The mean serum CG concentration in the postprandial sera of normal control subjects was 35±22ug/㎗(mean±SD) and no difference was noted between male and female. Serum CG values of the patients with hepatobiliary diseases were higher in the 2 hour postprandial samples than the fasting samples whether the fasting serum CG values were normal or not. However, the increment of serum CG values after meal was more pronounced among the patients with hepatobiliary diseases. 6) There was a good linear correlation between the level of serum CG and total bilirubin in hepatobiliary diseases. From this study it is concluded that serum CG test is a valuable and sensitive test in the diagnosis of various hepatobiliary diseases.
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