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Serum Levels of Immunoglobulins(IgG, IgA & IgM) and Complement C3 in Healthy Korean
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HOME > J Pathol Transl Med > Volume 16(2); 1982 > Article
Etc Serum Levels of Immunoglobulins(IgG, IgA & IgM) and Complement C3 in Healthy Korean
Journal of Pathology and Translational Medicine 1982;16(2):217-230
DOI: https://doi.org/
Department of Clinical Pathology, Chonnam University Medical School
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This study attempted to estimate the mean concentration of immunoglobulins and complement in healthy Korean. Serum concentrations of immunoglobulins and complements in healthy persons vary with age, race and sex. So, meaningful interpretation of serum levels of immunoglobulins and complements in infants and aged persons might have been difficult because of wide range of normal value. Recently, the great advance in methodology for the quantitation of immunoglobulins and complements has been achieved. In the present report, the concentrations of the immunoglobulin(IgG, IgA and IgM) and complement C3 were measured by Hyland Laser nephelometry in sera of 557 healthy Koreans from birth to 70 years of age. The results were as follows. 1) The concentration of IgG in adult sera was 1551.8±391.1㎎/100㎖(mean±S.D.) in male, 1720.0±385.6㎎/100㎖ in female; the level of IgM was 126.5±52.6㎎/100㎖ in male, 156.9±56.8㎎/100㎖ in female. The IgA value in adult sera was 250.6±105.7㎎/100㎖ in male, 269.1±97.9㎎/100㎖ in female; the mean level of C3 in adult sera was 103.4±27.1㎎/100㎖ in male and 105.5±28.0㎎/100㎖ in female. The levels of IgG and IgM were higher in adult females than in adult males(p<0.005). However, no significant differences were found on the levels of IgA and C3 between adult males and females(p>0.05). 2) The average level of IgG in cord sera was similar to that of adult sera and lowest at the 1 to 12 months of age, i.e., about 45 per cent of adult level. In the group of 6 to 12 years of age, the mean value of serum IgG approached the adult level in both sexes(p<0.005). 3) In cord sera, IgA could be detected in 53 per cent of all neonates. In the group of 1 to 12 months of age, serum IgA level revealed about 25 per cent of adult value and it was reached the adult level in the group of 13 to 18 years of age. No significant difference was observed on the IgA level throughout all age groups in both sexes(p>0.05). 4) IgM was detected in all cord sera with been less than 10 per cent of average adult level. The serum IgM level in adult female was significantly higher than that of adult male (p<0.005). 5) Concentration of C3 in cord sera was about 47 per cent of adult value and reached the adult level within one year. No significant difference was noted on the C3 level throughout all age groups in both sexes(p>0.05).

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