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The Korean Journal of Pathology 1982;16(2): 199-206.
비종양성 위점막에 출현하는 점액조의 형태학적 의의
Morphological Characteristics and Clinical Implication of Mucin Pool in Non-neoplastic Gastric Mucosa -Histotopographic Analysis of 180 Gastrectomy Specimens-
ABSTRACT
One hundred and eighty cases of surgically resected stomachs (129 cases of adenocarcinoma, 28 gastric ulcers and 21 chronic gastritis) were reconstructed by the extended histotopographic method along the distribution and morphological characteristics of mucin pool of leakage in the non-neoplastic gastric mucosa to identify the significance of mucin pools as a supportive evidence for the diagnosis of gastric carcinoma, especially in limited material such as endoscopic biopsy specimen. The intramucosal mucin pools were demonstrated 51.2% in the cases of gastric carcinoma and none in gastric ulcer of chronic gastritis. Those mucin pools were confined to the non-neoplastic mucosa adjacent to the carcinomatous lesions, and most of them (84.7%) were within 6㎜ from carcinoma. Background mucosal changes of stomachs with mucin pools were characterized by advanced intestinal metaplasia in all positive cases. The above findings may reflect that the presence of such mucin pools in non-neoplastic gastric mucosa of endoscopic biopsy specimens is an important and helpful and supportive evidence in the diagnosis of carcinoma.
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