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The Korean Journal of Pathology 1982;16(1): 19-26.
점액성 난소종양의 핵분열수에 따른 임상 및 병리학적 특성에 관한 연구
Clinicopathological Study of Primary Mucinous Ovarian Tumor According to the Number of Mitosis
ABSTRACT
After Scully divided the primary ovarian epithelial tumors into benign, borderline and malignant varieties, it has been repeatedly emphasized that there are appreciable differences in terms of prognosis in each group. However there may be individual difference among examiners when the pathological diagnosis is made on the basis of complex interpretation of the nuclear pleomorphism, mode of proliferation, frequency of mitosis and the presence of stromal invasion. In this study histological grading was made according to the frequency of mitosis, the most reliable index for the rate of cellular proliferation, in 98 mucinous ovarian tumors. Of the 98 subjects 80 cases belonged to the grade I (0~1 mitosis/HPF), and the grade II(2~3/HPF), III (4~5/HPF) and IV (> 5/HPF) tumors were seen in 11, 5 and 2 cases respectively. The degree of nuclear pleomorphism and the mode of cellular proliferation, such as the frequency and degree of papillary growth and secondary gland formation, corresponded well to the grades of tumors. Among the 98 mucinous tumors, seven cases (7.1%) showing stromal invasion were classified as malignant, irrespective of histologic grades, and all the grade I tumors but those with stromal invasion was grouped into benign, which comprised 80.6%. The remaining tumors were categorized into borderline malinancy which comprised 12.3% of all. The grade IV tumors showed smaller size and less multilocularity than the lower grade ones, suggesting that the higher-grade tumors tend to grow as solid mass rather than cystic locules. The short symptom-duration as well as the bilateral involvement were more likely of higher grade tumors. It was emphasized that one must pay regard to the frequency of mitosis when primary mucinous ovarian tumors were dealt with.