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The Korean Journal of Pathology 1981;15(1): 79-84.
매독과 동반된 발작성 한냉 혈색소 뇨증 1예 보고
A Case Report of Paroxysmal Cold Hemoglobinuria Associated with Syphilis
One case of rare autoimmune hemolytic syndrome, paroxysmal cold hemoglobinuria (PCH) is reported. PCH is one of the rarest of the autoimmune hemolytic syndrome, characterized by acute intermittent hemolysis, frequently with hemoglobinuria, abdominal pain and periodic attacks of fever, following local or general exposure to cold, and then a positive Donath-Landsteiner test, positive Ehrlich reaction test, occasionally positive Rosenbach test, and/or often associated with syphilis and recent viral infection. The present case was admitted with chief complaints of headache, dizziness and occasionally abdominal pain. According to several : laboratory findings, the case which we have presented here was thought to be compatible with paroxysmal cold hemoglobinuria associated with syphilis. The patient appeared to show poor clinical improvement in response to prednisolone in dose of 30mg per day, blood transfusion and other conservative management.