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The Korean Journal of Pathology 1981;15(1): 45-52.
간 질환에 있어서 혈청 총 LD 활성과 Isoenzymes에 관한 연구
Study on Serum Total LD Activity and Isoenzymes in Liver Diseases
The authors investigated total serum LD activity and isoenzymes in 5 cases of acute hepatitis, 14 cases of chronic hepatitis, 25 cases of liver cirrhosis, 17 cases of hepatocellular carcinoma and 20 cases of healthy control. The sera were obtained from the anterior cubital veins of the patients and healthy control in Busan National University Hospital from June 1978 to July 1979. Total Serum LD activity was measured by method of Caboud-Wroblewski and isoenzyme fractions were analysed by cellulose acetate electrophoresis. The results obtained were as follows : 1) In the patients with liver diseases, total serum LD activity was significantly increases than that of healthy controls. 2) In the patients with liver diseases LD1 and LD2 were significantly decreased than those of healtly controls, while LD4 and LD5 were significantly increased. 3) The patterns of serum LD isoenzyme fractions showed LD2>LD1>LD3>LD4>LD5 in healtly adult, LD5>LD2>LD1>LD3>LD4 in acute hepatitis and LD2>LD1>LD3>LD5>LD4 in chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. 4) In the patients with liver diseases, the ratio of LD1+LD2/LD4+LD5X100 was significantly decreased than that of healthy control. 5) The diagram for the percent distribution of serum LD isoenzymes demonstrated that all the fractions of LD isoenzymes except LD3 : in acute hepatitis and LD5 in other liver diseases were out range (M±2 SD) of healthy control. On the basis of above, the authors consider that total serum LD activity, isoenzymes and diagram for the percent distribution of isoenzymes may be help of clinically in making diagnosis and differention of various liver diseases.