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The Korean Journal of Pathology 1979;13(4): 463-467.
경산부의 면역항체
Immune Antibody in Multiparous Women
ABSTRACT
For the diagnosis of hemolytic disease of newborn especially due to ABO group incompatibility, presence of immune antibody in blood of mother and/or infant is essential. Rosner's modified 2-Mercaptoethanol reduction method is simple and sensitive. With this method we have conducted some basic stuffy of immune antibody in multiparous women with blood group 0 and The results are as fellows; 1) The mean immune antibody titer of group 0 multiparous women (1:8) is significantly higher than control group (1:2) who are group 0 girls without history of transfusion or pregnancy. 2) Mean immune antibody titer is significantly different according to their husband blood groups. Group 0-A couple has higher antibody titer (1:16) than group 0-B or group 0-0 couple 3) Immune antibody titer shorts no significant correlation with age, number of pregnancy or time lapse from last delivery. In conclusion a newborn who is born to group 0 mother and group A father is most subject to ABO hemolytic disease of newborn than other blood group combinations. Antenatal determination of immune antibody titer in group 0 mother could be helpful for the diagnosis and prediction of development of ABO hemolytic disease of newborn.
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