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The Korean Journal of Pathology 1979;13(4): 437-449.
간엽조직 종양의 분화에 따른 조직화학적 연구
Histochemical Study of Mesenchymal Tissue Tumors According to Differentiation
Based on histopathological and histochemical studies of 130 cases of benign and malignant tumors, which were submitted to the department of pathology, Yonsei University, College of Medicine during the period of 6 years and 6 months from Jan. 1972 to Jun. 1978, following results are obtained. 1. Among 130 cases, fibrocytic tumors were 46 cases, smooth muscle cell tumors, 23, and histiocytic tumors, 61. 2. Trichrome stain boomed to be more valuable to define the myofibrils and collagen fibers than van-Gieson stain, and reticulin stein is valuable for identifying the pattern of the tumor. 3. In smooth muscle cell tutors, leiomyoma and well differentiated leiomyosarcoma showed same staining character as normal smooth muscle cells, tut poorly differentiated ones revealed some degree of reduced stainabilily of the cytoplasm. 4. In fibrocytic tumors, poorly differentiated fitrosarcoma showed definitly reduced amount of collagen fibers than fibroma and well-differentiated fibrosarcoma. 5. Histiocytic tumors showed no appreciable difference in amount of collagen fiber in relation to its differentiation. In summary the special stains provided great diagnostic aid in differentrial diagnosis, however it is not always possible to define the histogenesis. Other specific diagnostic technics such as electron microscopy and tissue culture study were needed to accomplish more accurate diagnosis.