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The Korean Journal of Pathology 1977;11(3): 199-205.
만성일산화탄소 중독이 백서의 태반에 미치는 영향에 관한 병리조직학적 연구
Histopathologic Study of Chronic Carbon Monoxide Poisoning on the Placenta of the Rat
ABSTRACT
Carbon monoxide poisoning was the one of the most serious and important problem of public health of Korea because of the use of anthracite coal briquette as the main domestic fuel. There was strong presumtive clinical data that carbon monoxide poisoning during pregnancy can result in major malfomation secondary to apparent hypoxia. In attempting to unravel the mechanism behind the process of abortion, a careful study of the pathologic attention is the placenta would seem in seem in essential part. It was purpose of this report to describe the histologic changes in the placentas of the rats when animals were exposed to carbon monoxide in low concentration and long term during pregnancy. Experimental groups consists of 13 control and 18 pregnant rats. Animals were exposed to 1,000 ppm of carbon monoxide for 60 minutes daily throughout the gestational period. Pathologic changes in the placentas of rats of group of long term exposure of low concentrated carbon monoxide were summarized as follows : 1. In the labyrinth of exposure group were seen marked dilatation of maternal sinuses with vascular congestion and focal sinusoidal rupture, the degree of which were more promenent in the zone of periphery than central area. Sinusoidal walls near the basal zone showed moderate septal thickening as well as diffuse degeneration of trophoblasts such as nuclear swelling, pyknosis and loss of nucleoli. Isalnds of gylcogen cells and multinucleted giant cells were scattered throughout the labyrinth. 2. In the basal zone of exposure group were seen marked cytolysis of glycogen cells and degeneration of giant cells as well as marked vascular congestion and occasional thrombosis of maternal blood channels. Fibrinoid necrosis of decidua was relatively higher in the exposure group than the control rats. 3. In the epithelium of yolk sac was seen considerably intensified vacuolar degeneration in the exposure group than control ones. (This study was supported in part by the research grant (C.M.B. 74-332-5), the China Medical Board of New York)