A new method for measurement of total serum lipids was introduced by Flings and Dunn recently based on sulfo-phospho-vanillin reaction and colorimetric determination. Total serum lipids were determined by this is new method on 100 Korean adults and obtained mean 398 mg/100 ml and two standard deviation ±120 mg/100 ml. This new method seems speedy, simple, and reliable to compare with phenol turbidity method.