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The Korean Journal of Pathology 1970;4(2): 91-97.
Cytocidal Effect of Immune Lymphocytes on Transplantable Target Tumor Cells (Ehrlich Carcinoma and Sarcoma 180) in Vitro
ABSTRACT
It is one of remarkable contributions in recent advances on studies of tumor immunity(Klein and Klein, 1962; Prehn, 1963; old and Boyse, 1964). It is most desirable, if immunological treatment by which one can place hope on tumor repression in human subject is adoptive immunization by administration of homologous or heterologous immune lymphoid cells because it has been known that tumor immunity was mostly related to cell-mediated immunity(Coggin, J.H., Larson, V.M., and Hilleman, M.R.,1967). Littman, Kim and Suk (1968) reported that both UV-killed Sarcoma 180 and Ehrlich carcinoma ascites cells are powerfully potent in immunizing the mouse. Kim (1970) in our laboratory reported that the anti-rabbit UV-killed Sarcoma 180 and Ehrlich carcinoma ascites tumor cell-lymphocytes are so effective that both of the solid tumors of mice disappeared completely 30 days after the inoculation of tumors, especially in the group where lymphocytes were injected 14 days after tumor inoculation and the mechanism is the cytotoxic effect of sensitized lymphocytes on the target tumor cells. When this method is applied clinically, it is possible to obtain powerful immune lymphocytes on the target tumor cells by immunization against homologous or heterologous animals. Prior to clinical application, it is desirable to establish the appropriate method of in vitro tumor cell preservation and in vitro cytoxic test for detecting the potency of cell mediated immunity to tumor cells.
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