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The Korean Journal of Pathology 1968;2(2): 95-98.
The Regional Blood flow of the kidney Measurement, Disturbance and Pathology -A Radiological Method Newly explored-
Tadashi Takeuchi
1Department of Pathology, Nippon University School of Medicine
2Department of Physiology, Nippon University School of Medicine
3Department of Pathology Division of the National Institute of Radiological Scienc's
It is certainly desirable to know how the blood runs through in a certain territory of the kidney. This is better to call intrarenal regional blood flow. There were series of renal blood flow measurement proposed in the past which includes that of idea originating Homer Smith. The principle of these methods is in general based upon the fact that the blood flow is examined as a whole kidney, not taken some portion of it. The clearance method discloses renal blood flow of the entire kidney, not a part of it. The radiological method including Radiohippuran is also conducted by the similar principle giving information of the whole kidney. The gamma emitters such as radioiodine was employed along the same way of thought. What I am intending to know is the regional blood flow of the kidney, not of the kidney as a whole. With this reason invention, exploration were necessary. And rather longer time of endeavour was reguired. Reviewing the history Trueta and his colleagues have stated in 1948 that the renal blood flow running through the cortex differs conspicuously form that of medullary flow in clour by observing the renal venous blood. In conjunction with the intrarenal blood flow there was another idea proposed by Pappenheimer and Kinter in 1956 who studied this by measuring the intrarenal hematocrit at different portion of the kidney. The cell separation of the blood was what they reached in conclusion, Synonymed plasma skimming which is a peculiar vital phenomenon regulated by unknown mechanism of the blood vessel on one hand and by physical rheology on one other. It is unequivocally conceivable that intrarenal blood flow is markedly disturbed by at the state of shock, almost all kind of irradiation, allergic glomerulonephritis, pyelonephritis and even at the time of manipulation of ureter. I am convinced of that the irregularity of the intrarenal blood flow is certainly something to do with the pathogenesis of these pathological states and, therefore, of that the study of this field is obviously worthwhile to endeavous.
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