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The Korean Journal of Pathology 1996;30(9): 784-791.
Correlation between Histopathologic Grade, Stage, and Degree of EGFR Expression in Transitional Cell Carcinoma of the Urinary Bladder.
Hyeon Ok Kim, Hwa Sun Lee, Kang Suek Suh
Department of Pathology, Pusan National University College of Medicine, Pusan, Korea.
ABSTRACT
This study was performed to estimate the correlation between the histopathological grade and the clinical stage, which are known as important prognostic factors, and EGFR expression status in 57 cases of transitional cell carcinoma of the urinary bladder. There was a significant correlation between the histopathological grade and clinical stage of transitional cell carcinoma of the urinary bladder and between expression grades of EGFR and histopathological grades, or clinical stages of transitional cell carcinoma of the urinary bladder. Therefore, the presence of a high intensity of EGFR staining in the transitional cell carcinoma of the urinary bladder was associated with poor differentiation and invasion. On the basis of the above results, it was suggested that the degree of EGFR expression is one of the objective and reliable prognostic factors in transitional cell carcinoma of the urinary bladder.
Key Words: Transitional cell carcinoma; Urinary bladder; Epidermal growth factor receptor; Prognosis