| Home | E-Submission | Sitemap | Contact Us |  
The Korean Journal of Cytopathology 1995;6(2): 99-105.
Morphometry of Nuclei in Adenocarcinoma of Prostate.
Hye Rim Park, Seung Wan Char, Jin Hee Sohn, Young Euy Park
Department of Pathology, College of Medicine, Hallym University, Korea.
ABSTRACT
Morphometry of nuclei of the benign and malignant prostatic lesions was performed to study the relationship between nuclear size and shape and the prognosis of prostatic adenocarcinoma. Fifty one cases of prostatic adenocarcinoma and 13 cases of benign prostatic hyperplasia were included to evaluate area, perimeter, Dmax, Dmin, and 5 form factors of the nuclei by image analyzer(Zeiss Ibas 2000) using hematoxylineosin stained slides. All analytic factors of nuclear size and shape were significantly different between benign lesions and adenocarcinomas. Increased nuclear size was associated with nuclear irregularity, presence of metastasis, advanced clinical stage, and high Gleason's grade and score of prostatic adenocarcinoma. On Kaplan-Meier method, survival was decreased with older age, no hormonal treatment, stage D, high Gleason}s grade and stage as well as with larger size and irregular shape of the nuclei. In conclusion, morphometry of nuclei of the prostate can be a helpful tool to differentiate between benign and malignant lesions. Nuclear morphology is thought to be associated with prognosis of prostatic adenocarcinoma.
Key Words: Morphometry; Nucleus; Prostate
TOOLS
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
CrossRef TDM  CrossRef TDM
  E-Mail
Share:      
METRICS
783
View
2
Download
Related articles
A Case of Mucoepidermoid Carcinoma of the Bronchus  1984 December;18(4)
Rhabdomyosarcoma of Prostate  1982 September;16(3)
Micropapillary Mucinous Adenocarcinoma of the Lung: A Brief Case Report  2013 December;47(6)
Primary Thymic Mucinous Adenocarcinoma: A Case Report  2012 August;46(4)
Mucinous Adenocarcinoma in a Horseshoe Kidney.  2008 February;42(1)