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The Korean Journal of Pathology 1996;30(3): 276-278.
Malignant Melanoma of the Anus: Report of a case.
Eun Sun Jung, Byung Kee Kim, Sun Moo Kim, Sang In Shim
Department of Clinical Pathology, Catholic University Medical College, 137-701 Seoul, Korea.
This report describes a primary malignant melanoma which developed in the anus, as documented by light microscopy and immunohistochemistry. A 53-year-old woman had a 4 month history of a protruding mass in the anal canal. The mass was located in the squamo-columnar junction of the anal canal, measuring 5.0x4.5 cm. Its cut surface was dark brown and poorly circumscribed. The histologic appearance was characterized by epithelioid or spindle cells with prominant nucleoli and frequent atypical mitosis. Melanin pigments were strongly seen in Fontana-Masson stain. Immunoreactivity revealed that the cytoplasm of tumor cells was strongly positive with antibody directed against S-100 protein, vimentin and it was focally positive with neuron specific enolase.
Key Words: Malignant melanoma; Anus