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The Korean Journal of Pathology 1995;29(5): 607-614.
The Aberrant Expression of p53 Protein in Liver Cell Carcinoma.
Woo Young Jang, Dong Sug Kim, Ki Kwon Kim, Tae Sook Lee, Chang Yoon Kim, Hong Jin Kim
1Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea.
2Department of Preventive Medicine, Yeungnam University College of Medicine, Daegu, Korea.
3Department of General Surgery, Yeungnam University College of Medicine, Daegu, Korea.
ABSTRACT
This study was carried out to evaluate the aberrant expression of p53 protein using immunobistochemical method in 54 surgically resected liver cell carcinomas and to correlate it with clinical and pathological findings. Twenty five out of 54 cases(46%) showed positive reaction in the nucleus of liver cell carcinoma and negative reaction in associated 30 cases of cirrhosis, one case of adenoma and two cases of adenomatous hyperplasia. The p53 protein expression was associated with alpha-FP level(p<0.05), but not associated with HBsAg positivity. It was significantly associated with WHO classification, Edmondson-Steiner grade and nuclear grade p53(p<0.05), but not associated with tumor size, capsule formation, portal vein invasion, cirrhosis in surrounding tissue, Eggel classification, special cell type and mitosis. In conclusion, our results suggest that the aberrant expression of p53 protein can be an advisory factor, at least, for prognosis evaluation.
Key Words: p53; Liver cell carcinoma; Liver