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The Korean Journal of Cytopathology 1995;6(1): 1-9.
p 53 Protein Expression in Imprint Cytology of Breast Carcinoma.
Dong Sug Kim, Eun Hi Lee, Ki Kwon Kim, Mi Jin Kim, Soo Jung Lee
1Department of Pathology, Yeungnam University College of Medicine, Korea.
2Department of General Surgery, Yeungnam University College of Medicine, Korea.
This study was carried out to determine the usefulness of imprint cytology for detecting p 53 protein in breast carcinoma. NCL-DO7(Novocastra, U.K.) was used to detect p53 protein immunocytochemically. A total of 33 cases was studied. Immunostaining of imprint cytology with NCL-DO7 was positive in 64%(2133) and showed relatively high coincident rate (80 %) with immunostaining of formalin-fixed, paraffin - embedded specimen. p 53 protein was related to negative estrogen receptor status, but not to the nuclear grade, lymph node metastasis, or tumor size. The fact that p53 protein expression was not related to nuclear grade might be due to predominance of nuclear grade 3. It was easier to determine the nuclear grade is one of the most important prognostic factors, in imprint cytology than in tissue specimen. p53 protein tended to be stained more strongly in imprint cytology than in tissue.
Key Words: Breast carcinoma; Imprint cytology; p53 protein; Immunocytochemistry