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The Korean Journal of Pathology 1994;28(6): 612-619.
Relationship between Immunohistochemical Expression of Cathepsin D and Other Prognostic Factors of Breast Carcinoma.
Kwang Hwa Park, Byeng Woo Park, Kyong Sik Lee, Kwang Gil Lee
1Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
2Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
3Department of Surgery, College of Medicine Ehwa University, Seoul, Korea.
The cathepsin D is a lysosomal protease secreted in excess by breast cancer cells. The function of this enzyme is degradation of the extracellular matrix and proteoglycan. It is induced by estrogens in estrogen receptor positive breast cancer cell lines. On the basis of this, cathepsin D expression in breast cancer cells seems to be correlated with the prognosis. But there is debates in its prognostic significance. Relationship between cathepsin D expression and other prognostic factors of breast cancer was studied. We investigated 51 cases of invasive ductal cell carcinoma of breast removed by open biopsy or mastectomy. All cases were fixed in formalin and embedded in paraffin. We used 46-KD intermediate form of the enzyme for cathepsin D expression on immunohistochemical stain. We observed no significant correlation with age, stage, histologic grade, lymphatic invasion, and estrogen receptor status. Cathepsin D may be an independent factor which is not related with other prognostic factors, especially estrogen receptor status.
Key Words: Cathepsin D; Immunohistochemistry; Breast cancer; Estrogen receptors; Prognostic factors