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The Korean Journal of Pathology 1994;28(5): 506-510.
Interstitial Mononuclear Cell Infiltration and its Phenotypes in IgA Nephropathy.
Hyeon Joo Jeong, Hyunee Yim, Sun Hee Sung, In Joon Choi
Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
ABSTRACT
To know the correlation between glomerular and tubulointerstitial lesion and to define the characteristics of interstitial inflammatory cell in IgA nephropathy and classified according to WHO classification and graded tubulointerstitial lesion as mild, moderate and severe. Paraffin-embedded 5u sections were stained with UCHL-l, L26 and CD68 antibodies. More than 20 fields were examined in each case under the high power microscopy and the number of positive cells were counted. There was positive correlation between the severity of glomerular and that of tubulointerstitial lesion. The mostcommoninflammatory cells in the interstitiuin were UCHL-l positive cells followed by CD68 and L26 positive cells. As the WHO grade or tubulointerstitial lesion increased, the numbers of positive cells were increased in all three groups. The proportion of UCHL-1 Positive cells were increased in cases with high WHO grade whereas that of L26 positive cells incases with severe tubulointerstitial lesion Proteinuria was correlated with the degree of inflammatory cell infiltration, especially with that of L26 positive cells.
Key Words: IgA nephropathy; Mononuclear cell; Tubulointerstitial lesion; Immunohistochemistry
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