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The Korean Journal of Pathology 1994;28(4): 439-441.
Congenital Cytomegalic Inclusion Disease combined with Hydrocephalus: A case report.
Kam Rae Cho, Cheol Hee Yun, Sang Pyo Kim, Kwan Kyu Park, Eun Sook Chang, Taek Hoon Kim
Department of Pathology, Obstetrics and Gynecology Keimyung University School of Medicine, Taegu, Korea.
This is an autopsy-verifed case of the generalized cytomegalic inclusion disease occuring in a male fetus of a weeks gestation. The fetus revealed hydrocephalus and focal necrosis of brain, focal subcapsular necrosis of liver, and the typical cytomegalic inclusion cells having large acidophilic intranuclear inclusions in the liver, brain, kidney, lung, adrenal gland, pancreas and chorionic villi. Prominent extramedullary hematopoiesis was noted in the liver and kidney. Immuohistochemical staining using anti-cytomegalovirus antibody revealed intranuclear or occasionally intracytoplasmic immunoreactivity in brain, liver, pancreas, lung, kidney, and intestine.
Key Words: Cytomegalovirus; Congenital; Hydrocephalus; Inclusion; Autopsy