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The Korean Journal of Pathology 1994;28(4): 409-413.
Gagtric Adenocarcinoma with Choriocarcinomatous and Hepatoid Differentiation: Report of a case.
Kyeong Cheon Jung, Woo Ho Kim, Yong Il Kim, Kook Jin Choe
1Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
2Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
ABSTRACT
Association of the hepatoid and choriocarcinomatous components in adenocarcinoma of the stomach is extremely unusual and raises a possibility of new approach understand the histogenesis of gastric hepatoid adenocarcinoma. This paper describes a Borrmann type III adenocarcinoma of the stomach with both choriocarcinomatous and hepatoid components in composite tumor pattern in a 50-year-old man. Tubular arrangement of differentiated embryonalcarcinoma was encountered in choricarcinomatous and hepatoid areas, which showed strong immunoreactivity to beta-HCG and AFP, respectively. The findings suggest that gastric adenocarcinoma may have a potential of differentiation toward embryonal carcinoma. from which both choriocarcinoma and hepatoid variant of gastric adenocarcinoma may develop by retrodifferentiation.
Key Words: Stomach; Hepatoid'adenocarcinoma; Choriocarcinoma; Retrodifferentiation