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The Korean Journal of Pathology 1994;28(3): 316-318.
Glycogen-Rich Clear Cell Carcinoma of Breast: A case report.
Nam Hoon Kim, Wan Seop Kim, Young Hyeh Ko, Jung Dal Lee
Department of Pathology, HanYang University College of Medicine, Seoul, Korea.
Glycogen-rich clear cell carcinoma of the breast is very rare(l -3% of breast cancer). It is defined as a tumor composed of more than 50% of optically clear, neoplastic cells, characterized by centrally located nuclei and abundant cytoplasm, being positive for periodic acid Schiff(PAS) and negative for periodic acid Schiff after diastase(D-PAS) treatment. In the absence of intraductal or in situ lobular carcinoma component, metastatic clear cell carcinomas of other organs should be considered as diagnostic possibilities. We report a case of glycogen-rich clear cell carcinoma arisen in a 62-year-old woman. The tumor revealed both solid and papillary pattern with intraductal component. The neoplastic cells had clear cytoplasm, which were PAS positive, D-PAS negative, mucicarmine negative and oil red 0 negative. More than 90% of tumor cells exhibited moderate staining for anti-estrogen receptor monoclonal antibody. Flow cytometric DNA analysis revealed diploid DNA content.
Key Words: Breast; Clear cell carcinoma; Glycogen-rich cell; Estrogen-receptor