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The Korean Journal of Pathology 1994;28(2): 149-153.
Expression of Trans forming Growth Factor-a and Proliferating Cell Nuclear Antigen in Human Gliomas.
Gyeong Sin Lee, Byung Hyun Kim, Bong Kwon Chun, Man Ha Huh
1Department of Pathology, Kosin Medical College, Pusan, Korea.
2Masan Koryo General Hospital, Korea.
3Maryknoll Hospital.
To evaluate the expression of transforming growth factor-alpha(TGF-alpha) and proliferating cell nuclear antigen(PCNA) and its relation to the differentiation of the tumors, immunohistochemical studies were performed in 49 human gliomas. Tumors were graded by a 3-grade-system; grade I=low grade glioma, grade Il=anaplastic glioma, grade III=glioblastoma multiforme. TGF-A and PCNA were predominantly expressed in malignant gliomas compared with benign gliomas. Malignant gliomas revealed 87% TGF-A reactivity, while benign gliomas revealed 26% TGF-A reactivity. The proliferation index with PCNA was 26%+/-7%(mean+/-standard deviation) in malignant gliomas and 5%?% in benign gliomas. A strong positive correlation between tumor grade and extent of TGF-A and PCNA expression was found(P<0.0001, Chi square and P<0.002, T-test). Synchronous expression of TGF-A and PCNA was observed in 16 cases(33%). The results of this study support the suggestion that the expression of TGF-A might be a useful prognostic indicator in human gliomas.
Key Words: TGF-A; PCN A; Gliomas; Immunohistochemistry