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The Korean Journal of Pathology 1994;28(1): 82-85.
Localized Pseudopolyposis of the Ascending Colon Associated with Granulomatous Colitis: A case report.
Jeong Ja Kwak, Kye Hyun Kwon, So Young Jin, Dong Wha Lee
Department of Anatomical Pathology, Soonchunhyang University Hospital, Seoul, Korea.
Pseudopolyps represent discrete areas of mucosal inflammation and regeneration that are seen in a variety of inflammatory bowel disease including ulcerative colitis and Crohn's disease. These polyps are typically short, measuring less than 1.5 cm in height. Rarely, localized giant pseudopolyposis can occur, i.e., a collection of larger inflammatory pseudopolyps giving rise to a mass lesion within the colon. The most serious problem concerned with pseudopolyposis is a confusion with carcinoma. We experienced a case of localized giant pseudopolyposis causing partial large bowel obstruction. Right hemicolectomy was done for a preoperative diagnosis of ascending colon carcinoma. The resected specimen contained a circumferential lesion, which was composed of numerous interconnecting cylindrical villi, measuring 12 cm in length and 3 cm in height. Microscopically, these polypoid lesions were inflammatory pseudopolyps. Several deep fissure-like ulcerations were noted with multifocal microabscess, lymphoid hyperplasia and an area of noncaseating granuloma.
Key Words: Localized giant pseudopolyposis; Granulomatous colitis; Carcinoma