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The Korean Journal of Cytopathology 1990;1(1): 93-97.
골 거대세포종의 2예 세침 천자 세포학적 소견
명나혜1, 하창원1, 조경자1, 장자준1, 백구현2, 이수용2
1원자력병원 해부병리과
2원자력병원 정형외과
Two Cases of Giant Cell Tumor of the Bone Diagnosed by Fine Needle Aspiration Cytology.
Na Hye Myong1, Chang Won Ha1, Kyung Ja Cho1, Ja June Jang1, Goo Hyun Baek2, Soo Yong Lee2
1Department of Anatomical Pathology, Korea Cancer Center Hospital, Korea.
2Department of Orthopedic Surgery, Korea Cancer Center Hospital, Korea.
Two cases of giant cell tumor of bone diagnosed by fine needle aspiration cytology are described. Case 1 was a 28-year -old male who had pain sense for one year at the right distal thigh. His radiologic finding revealed a destructive cortical lesion with soft tissue extension at medial side of epiphysis of the distal femur. Case 2 was a 21-year-old female complaining pain at left distal forearm for eight months and showed a well-demarcated expansile osteolytic lesion with multisepatation, and cortical destruction at epiphysis and metaphysis of the left distal radius on the X-ray. Fine needle aspiration of each lesion was performed. The aspirate of the case 1 reveated moderate cellularity, which was composed of scattered giant cells of osteoclastic type and small round to oval monotonous stromal cells in large areas. Giant cells were evenly distributed in single or small groups and had irregular but abundant cytoplasms with 10 to 20 nuclei in the center. The nuclei showed ovoid shape, fine granular chromatin, and a small but conspicuous nucleolus, Stromal cells were dispersed in isolated pattern or sometimes aggregated in clusters and showed the same nuclei as those of giant cells and scanty cytoplasms, Comparing to case 1, case 2 had a more translucent abundant cytoplasm in the giant cells and more spindled stromal cells, All two cases revealed neither nuclear atypism nor increased abnormal mitoses in both giant and stromal cells, suggesting no evidence of malignancy. Thereafter the lesions were treated with excision and curettage and histologically confirmed as giant cell tumors of the bone.
Key Words: Giant cell tumor; Aspiration cytology