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The Korean Journal of Pathology 1993;27(2): 164-168.
Inflammatory Pseudotumor of the Lymph Node: A case report.
Yee Jeong Kim, Kun Chang Song, Woo Hee Jung, Woon Sup Han
1Department of Pathology, College of Medicine, Yonsei University, Seoul, Korea.
2Department of Pathology, College of Medicine, Ewha Women's University, Seoul, Korea.
ABSTRACT
A 21-year-old man presented with a 7 days history of fever. Careful clinical examination led to the discovery of left supraclavicular lymphadenopathy without hepatosplenomegaly. Serologic tests for Ebstein-Barr virus, HIV, hepatitis type B & C, syphilis and typhoid fever were negative. Blood, urine, and stool cultures yielded no growth. Histologically, the process mainly involved the connective tissue framework of the lymph node, sharing the features of inflammatory pseudotmor(IPT) of other organs: a storiform growth pattern, increased vascularity with associated vascular lesions, and a polymorphous inflammatory infiltrate in a collagen-rich stroma. Immunohistochemical study for spindle cells showed positive reaction for actin and vimentin but not for desmin, and lymphoid cells revealed polyclonality. Characteristics of mass formation, and the inflammatory nautre of the process enabled us adopt the term IPT which should be differentiated from hematolymphoid proliferative disorder or mesenchymal neoplasia.
Key Words: Inflammatory pseudotumor; Lymph node; Immunohistochemistry