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JPTM > Volume 53(1); 2019 > Article
Journal of Pathology and Translational Medicine 2019;53(1): 50-56.
doi: https://doi.org/10.4132/jptm.2018.11.30
Quilty Lesions in the Endomyocardial Biopsies after Heart Transplantation
Haeyon Cho1 , Jin-Oh Choi2 , Eun-Seok Jeon2 , Jung-Sun Kim1,3
1Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
2Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
3Department of Health Sciences and Technology, Sungkyunkwan University, SAIHST, Seoul, Korea
Corresponding Author: Jung-Sun Kim ,Tel: +82-2-3410-2767, Fax: +82-2-3410-0025, Email: jsunkim@skku.edu
Received: September 3, 2018;  Revised: November 28, 2018  Accepted: November 30, 2018.  Published online: December 26, 2018.
ABSTRACT

Background:
The aim of this study was to investigate the clinical significance of Quilty lesions in endomyocardial biopsies (EMBs) of cardiac transplantation patients.
Methods:
A total of 1190EMBs from 117 cardiac transplantation patients were evaluated histologically for Quilty lesions,acute cellular rejection, and antibody-mediated rejection. Cardiac allograft vasculopathy wasdiagnosed by computed tomography coronary angiography. Clinical information, including thepatients’ survival was retrieved by a review of medical records.
Results:
Eighty-eight patients(75.2%) were diagnosed with Quilty lesions, which were significantly associated with acute cellularrejection, but not with acute cellular rejection ≥ 2R or antibody-mediated rejection. In patientsdiagnosed with both Quilty lesions and acute cellular rejection, the time-to-onset of Quilty lesionsfrom transplantation was longer than that of acute cellular rejections. We found a significant associationbetween Quilty lesions and cardiac allograft vasculopathy. No significant relationship wasfound between Quilty lesions and the patients’ survival.
Conclusions:
Quilty lesion may be an indicator of previous acute cellular rejection rather than a predictor for future acute cellular rejection.
Key Words: Quilty lesion; Endocardial inflammatory infiltrates; Acute cellular rejection; Cardiac allograft vasculopathy; Heart transplantation
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