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JPTM > Volume 53(2); 2019 > Article
Journal of Pathology and Translational Medicine 2019;53(2): 119-124.
doi: https://doi.org/10.4132/jptm.2018.10.18
Primary Malignant Melanoma of the Breast: A Report of Two Cases
Jiwon Koh1 , Jihyeon Lee2, So Youn Jung3, Han Sung Kang3, Tak Yun4 , Youngmee Kwon2,3
1Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
2Department of Pathology, National Cancer Center, Goyang, Korea
3Center for Breast Cancer, National Cancer Center, Goyang, Korea
4Center for Specific Organs Center, National Cancer Center, Goyang, Korea
Corresponding Author: Youngmee Kwon ,Tel: +82-31-920-1742, Fax: +82-31-920-1369, Email: ymk@ncc.re.kr
Received: September 26, 2018;  Revised: October 13, 2018  Accepted: October 18, 2018.  Published online: November 26, 2018.
Primary malignant melanoma of the breast (PMMB) is a rare tumor with only a few case reports available in the literature. We report two cases of PMMB, one derived from the breast parenchyma and the other from the breast skin. The first case consisted of atypical epithelioid cells without overt melanocytic differentiation like melanin pigments. The tumor cells showed diffuse positivity for S100 protein, tyrosinase, and BRAF V600E. However, the tumor cells were negative for cytokeratin, epithelial membrane antigen, and HMB-45. The second case showed atypical melanocytic proliferation with heavy melanin pigmentation. The tumor cells were positive for S100 protein, HMB-45, tyrosinase, and BRAF V600E. These two cases represent two distinct presentations of PMMB in terms of skin involvement, melanin pigmentation, and HMB-45 positivity. Although PMMB is very rare, the possibility of this entity should be considered in malignant epithelioid neoplasms in the breast parenchyma.
Key Words: Breast; Malignant melanoma; BRAF