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JPTM > Ahead-of Print

doi: https://doi.org/10.4132/jptm.2017.11.10    [Epub ahead of print]
Merkel Cell Carcinoma Metastatic to Pleural Fluid: A Case Report
Ye-Young Rhee1, Soo Hee Kim1, Eun Kyung Kim2, Se Hoon Kim2
1Pathology Center, Seegene Medical Foundation, Seoul, Korea
2Department of Pathology, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea
Corresponding Author: Se Hoon Kim ,Tel: +82-2-2228-1769, Fax: +82-2-362-0860, Email: paxco@yuhs.ac
Received: October 11, 2017;  Revised: November 7, 2017  Accepted: November 9, 2017.  Published online: November 23, 2017.
Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine carcinoma of the skin that shows locoregional and distant metastasis. Metastasis of MCC to body cavity effusion is extremely rare; only three cases had been reported so far. Metastatic MCC in effusion cytology shows small blue round cells with fine stippled chromatin like other small blue round cell tumors such as small cell lung carcinoma or lymphoma. The diagnosis of metastatic MCC could give patients good chances to get recently advanced therapeutic options. Here, we present a case of metastatic MCC to pleural effusion with characteristic single file-like pattern.
Key Words: Merkel cell carcinoma, Metastasis, Pleural fluid, Liquid-based cytology