Journal of Pathology and Translational Medicine

Original Articles

TNF-α and TNF-β Polymorphisms are Associated with Susceptibility to Osteoarthritis in a Korean Population: Lin Han, Joo Hyoun Song, Jung Hwan Yoon, Yong Gyu Park, Suk Woo Lee, Yoo Jin Choi, Suk Woo Nam, Jung Young Lee, Won Sang Park; Korean J Pathol. 2012;46(1):30-37. Published online February 23, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.30

9,441 View
41 Download
27 Crossref

Background

The tumor necrosis factor (TNF) is believed to play an important role in the pathophysiology of osteoarthritis (OA). Evidence shows that genetic polymorphisms make substantial contributions to the etiology of OA.

Methods

We investigated the genotypes TNF-α and TNF-β in 301 OA patients and 291 healthy subjects as controls. We employed a polymerase chain reaction-restriction fragment length polymorphism and a polymerase chain reaction-single strand conformation polymorphism assay to identify the genotypes TNFA -G308A and TNFB +G252A, respectively.

Results

For TNFA -G308A, the percentages of genotypes GG, AG, and AA were 26.3% (79/301), 62.5% (188/301), and 11.3% (34/301) in OA patients and 88.7% (258/291), 11.3% (33/291), and 0% (0/291) in controls. For TNFB +G252A, the percentages of genotypes GG, AG, and AA were 15.3% (46/301), 41.9% (126/301), and 42.9% (129/301) in OA patients and 12% (35/291), 52.6% (153/291), and 35.4% (103/291) in controls. There were significant differences in genotypes and alleles of TNFA -308 between OA patients and controls (p<0.0001) and in alleles of TNFB +252 (p=0.0325). The risk of OA was significantly higher for carriers of the TNFA -308A allele and the TNFB +252 AA homozygote (p=0.0224).

Conclusions

The results suggest close relationships between TNFA -G308A and TNFB +G252A polymorphisms and individual susceptibility to OA in the Korean population.

Citations

Citations to this article as recorded by

Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review
Phaniendra Alugoju, V. K. D. Krishna Swamy, Naga Venkata Anusha Anthikapalli, Tewin Tencomnao
Critical Reviews in Food Science and Nutrition.2023; 63(31): 10709. CrossRef
Complete sequence and comparative analysis of the mitochondrial genome of the rare and endangered Clematis acerifolia, the first clematis mitogenome to provide new insights into the phylogenetic evolutionary status of the genus
Dan Liu, Kai Qu, Yangchen Yuan, Zhiheng Zhao, Ying Chen, Biao Han, Wei Li, Yousry A. El-Kassaby, Yangyang Yin, Xiaoman Xie, Boqiang Tong, Hongshan Liu
Frontiers in Genetics.2023;[Epub] CrossRef
Intra-articular Treatment with Triamcinolone Hexacetonide Associated with Gold Nanoparticles Reduces Cartilage Degeneration in an Animal Model of Osteoarthritis
Daniela Pacheco dos Santos Haupenthal, Marcus Barg Resmini, Leandro Almeida Da Silva, Mateus Cardoso Colares, Laura de Roch Casagrande, Ligia Milanez Venturini, Thiago Antônio Moretti de Andrade, Fernando Russo Costa do Bomfim, Anand Thirupathi, Paulo Emi
Current Drug Targets.2023; 24(3): 287. CrossRef
Vitamin D Receptor Gene Polymorphisms and Risk of Knee Osteoarthritis: Possible Correlations with TNF-α, Macrophage Migration Inhibitory Factor, and 25-Hydroxycholecalciferol Status
Mohammed H. Hassan, Amer Alkot Mostafa Elsadek, Marwa Ahmed Mahmoud, Bakheet E. M. Elsadek
Biochemical Genetics.2022; 60(2): 611. CrossRef
Complement System Inhibition Modulates the Inflammation Induced by the Venom of Premolis semirufa, an Amazon Rainforest Moth Caterpillar
Joel J. M. Gabrili, Isadora Maria Villas-Boas, Giselle Pidde, Carla Cristina Squaiella-Baptistão, Trent M. Woodruff, Denise V. Tambourgi
International Journal of Molecular Sciences.2022; 23(21): 13333. CrossRef
Azilsartan prevented AGE‐induced inflammatory response and degradation of aggrecan in human chondrocytes through inhibition of Sox4
Jie Lei, Mengyin He, Liangzhou Xu, Chengjian He, Jie Li, Wei Wang
Journal of Biochemical and Molecular Toxicology.2021;[Epub] CrossRef
TNF-α Carried by Plasma Extracellular Vesicles Predicts Knee Osteoarthritis Progression
Xin Zhang, Ming-Feng Hsueh, Janet L. Huebner, Virginia B. Kraus
Frontiers in Immunology.2021;[Epub] CrossRef
Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis
Chih-Chien Wang, Chih-Yun Huang, Meng-Chang Lee, Dung-Jang Tsai, Chia-Chun Wu, Sui-Lung Su, Mingqing Xu
PLOS ONE.2021; 16(11): e0259561. CrossRef
Sex-, Age-, and Metabolic Disorder-Dependent Distributions of Selected Inflammatory Biomarkers among Community-Dwelling Adults
So Mi Jemma Cho, Hokyou Lee, Jee-Seon Shim, Hyeon Chang Kim
Diabetes & Metabolism Journal.2020; 44(5): 711. CrossRef
Tumor necrosis factor-α: Molecular assessment of gene expression, genetic variants and serum level in Egyptian patients with knee osteoarthritis
Nermin Raafat, Amal F. Gharib, Doaa S. Atta, Shimaa M. AbdElwahab, Doaa M. Sharaf
Gene Reports.2020; 21: 100922. CrossRef
Effect of a functional variant of tumor necrosis factor‐β gene in temporomandibular disorders: A pilot study
Kaan Yerliyurt, Ayse Feyda Nursal, Akin Tekcan, Nevin Karakus, Mehmet K. Tumer, Serbulent Yigit
Journal of Clinical Laboratory Analysis.2019;[Epub] CrossRef
Interleukin-6 (-572) and Tumor Necrosis Factor α (-308 and -238) Polymorphisms and Risk of Knee Osteoarthritis in a Pakistani Population: A Case–Control Study
Syeda Kanwal Batool Naqvi, Maria Bibi, Iram Murtaza, Qamar Javed
Iranian Journal of Science and Technology, Transactions A: Science.2019; 43(4): 1485. CrossRef
Role of resistin genetic variations in knee osteoarthritis pathogenesis, a cross sectional study
Syeda Kanwal Batool Naqvi, Iram Murtaza, Qamar Javed
Molecular Biology Reports.2019; 46(3): 2657. CrossRef
Relationship Between Genetic Polymorphisms of the TNF Gene and Hallux Valgus Susceptibility
Jie Yang, Junhu Wang, Xiaojun Liang, Hongmou Zhao, Jun Lu, Qiang Ma, Feng Tian
Genetic Testing and Molecular Biomarkers.2019; 23(6): 380. CrossRef
Functional status and severity of osteoarthritis in elderly is associated to the polymorphism of TNFA gene
Marcos Tadeu Parron Fernandes, Karen Barros Parron Fernandes, Fernanda Freitas Anibal, Walquíria Shimoya-Bittencourt, Viviane Martins Santos, Priscila Daniele de Oliveira Perrucini, Regina Célia Poli-Frederico
Advances in Rheumatology.2019;[Epub] CrossRef
Association of TNF-α-308 G > A and −238G > A polymorphisms with knee osteoarthritis risk: A case-control study and meta-analysis
Mohammad Reza Sobhan, Masoud Mahdinezhad-Yazdi, Kazem Aghili, Masoud Zare-Shehneh, Shohreh Rastegar, Jalal Sadeghizadeh-Yazdi, Hossein Neamatzadeh
Journal of Orthopaedics.2018; 15(3): 747. CrossRef
Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population
Jie Chen, Yu Wu, Jiannong Yu, Jinming Shen
Brazilian Journal of Medical and Biological Research.2018;[Epub] CrossRef
Association of cytokine gene polymorphisms with osteoarthritis susceptibility
Otilia Rogoveanu, Daniela Calina, Mihai Cucu, Florin Burada, Anca Docea, Simona Sosoi, Emilian Stefan, Mihai Ioana, Emilia Burada
Experimental and Therapeutic Medicine.2018;[Epub] CrossRef
TNF‑α increases the expression of inflammatory factors in synovial fibroblasts by inhibiting the PI3K/AKT pathway in a rat model of monosodium iodoacetate‑induced osteoarthritis
Hongxi Li, Shujuan Xie, Yunlong Qi, Huazhe Li, Rui Zhang, Yongyun Lian
Experimental and Therapeutic Medicine.2018;[Epub] CrossRef
The single-nucleotide polymorphism (SNP) of tumor necrosis factor α −308G/A gene is associated with early-onset primary knee osteoarthritis in an Egyptian female population
Sahar M. Abdel Galil, Nillie Ezzeldin, Faten Fawzy, Mohamed El-Boshy
Clinical Rheumatology.2017; 36(11): 2525. CrossRef
Roxatidine Attenuates Degradation of Extracellular Matrix
Renhao Ze, Shangyu Wang, Mao Xie, Bo Zhang, Xin Tang, Jin Li
Biomedicine & Pharmacotherapy.2017; 95: 1156. CrossRef
The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis
Piotr Wojdasiewicz, Łukasz A. Poniatowski, Dariusz Szukiewicz
Mediators of Inflammation.2014; 2014: 1. CrossRef
Meta-analysis of tumor necrosis factor alpha -308 polymorphism and knee osteoarthritis risk
Suotang Kou, Yaochi Wu
BMC Musculoskeletal Disorders.2014;[Epub] CrossRef
Astaxanthin reduces matrix metalloproteinase expression in human chondrocytes
Wei-Ping Chen, Yan Xiong, Yong-Xiang Shi, Peng-Fei Hu, Jia-Peng Bao, Li-Dong Wu
International Immunopharmacology.2014; 19(1): 174. CrossRef
Variations in the TNFα gene and their interactions with the IL4R and IL10 genes in relation to hand osteoarthritis
Satu Hämäläinen, Svetlana Solovieva, Tapio Vehmas, Päivi Leino-Arjas, Ari Hirvonen
BMC Musculoskeletal Disorders.2014;[Epub] CrossRef
Tumor necrosis factor gene polymorphisms and endometriosis in Asians: a systematic review and meta-analysis
Jiangtao Lyu, Hua Yang, Jinghe Lang, Xianjie Tan
Chinese Medical Journal.2014; 127(9): 1761. CrossRef
Association analysis of two candidate polymorphisms in the Tumour Necrosis Factor-α gene with osteoarthritis in a Chinese population
Bin Ji, Jixiang Shi, Xiangyu Cheng, Junjie Zhou, Qiang Zhou, Chengfu Cao, Jinhui Pang
International Orthopaedics.2013; 37(10): 2061. CrossRef

Growth Differentiation Factor 5 (GDF5) Core Promoter Polymorphism Is Not Associated with Susceptibility to Osteoarthritis of the Knee in the Korean Population.: Zhang Cao, Hwa Sung Lee, Jae Hwi Song, Jeong Whan Yoon, Yong Kyu Park, Suk Woo Nam, Jung Young Lee, Won Sang Park; Korean J Pathol. 2010;44(4):404-409.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.4.404

4,083 View
22 Download
9 Crossref

Abstract PDF

BACKGROUND
Osteoarthritis (OA) is a common disease characterized by degenerating joint cartilage in the knee, hip, and hand. A functional single nucleotide polymorphism (SNP) +104T/C; rs143383 in the 5' untranslated region of the growth differentiation factor 5 (GDF5) gene was recently associated with susceptibility to OA in the Japanese and Chinese populations.
METHODS
To investigate whether this association is present in the Korean population, the frequency of the polymorphism was investigated in 276 patients with knee OA and 298 healthy subjects as controls. Polymorphism analysis was performed by amplifying the core promoter region of the GDF5 gene and digesting it with the BsiEI restriction enzyme.
RESULTS
The frequency of the TT, CT, and CC genotypes was 54.3% (150/276), 41.7% (115/276), and 4.0% (11/276), respectively, in patients with OA, and 53.4% (159/298), 37.9% (113/298), and 8.7% (26/298), respectively, in healthy controls. No significant differences in genotypic or allelic frequencies of the +104T/C SNP of the GDF5 gene were observed between patients with OA and controls. Also, no significant differences in allelic and genotypic frequencies were found when the individuals were stratified by age and gender.
CONCLUSIONS
The results suggest that the +104T/C; rs143383 GDF5 core promoter polymorphism is not a risk factor for OA in the Korean population.

Citations

Citations to this article as recorded by

The association of growth differentiation factor 5 rs143383 gene polymorphism with osteoarthritis: a systematic review and meta-analysis
Yue-peng Wang, Wen-jia Di, Su Yang, Shi-lei Qin, Yun-feng Xu, Peng-fei Han, Ke-dong Hou
Journal of Orthopaedic Surgery and Research.2023;[Epub] CrossRef
Correlation between growth differentiation factor 5 (rs143383) gene polymorphism and knee osteoarthritis: an updated systematic review and meta-analysis
Bin Jia, Yaping Jiang, Yingxing Xu, Yingzhen Wang, Tao Li
Journal of Orthopaedic Surgery and Research.2021;[Epub] CrossRef
Association between GDF5 rs143383 genetic polymorphism and musculoskeletal degenerative diseases susceptibility: a meta-analysis
Xin Huang, Weiyue Zhang, Zengwu Shao
BMC Medical Genetics.2018;[Epub] CrossRef
Association of BMP-14 rs143383 ploymorphism with its susceptibility to osteoarthritis
Yi Yin, Yan Wang
Medicine.2017; 96(42): e7447. CrossRef
Association between GDF5 +104T/C polymorphism and knee osteoarthritis in Caucasian and Asian populations: a meta-analysis based on case-control studies
Dong Jiang, Zengtao Hao, Dongsheng Fan, Wen Guo, Pengcheng Xu, Chao Yin, Shuzheng Wen, Jihong Wang
Journal of Orthopaedic Surgery and Research.2016;[Epub] CrossRef
A comprehensive meta-analysis of association between genetic variants of GDF5 and osteoarthritis of the knee, hip and hand
Rui Zhang, Jianfeng Yao, Peng Xu, Baohu Ji, James V. Luck, Brian Chin, Shemin Lu, John R. Kelsoe, Jie Ma
Inflammation Research.2015; 64(6): 405. CrossRef
Association between GDF5 rs143383 polymorphism and knee osteoarthritis: an updated meta-analysis based on 23,995 subjects
Feng Pan, Jing Tian, Tania Winzenberg, Changhai Ding, Graeme Jones
BMC Musculoskeletal Disorders.2014;[Epub] CrossRef
Association between the +104T/C polymorphism in the 5′UTR of GDF5 and susceptibility to knee osteoarthritis: A meta-analysis
SHAO-WEN HAO, QUN-HUA JIN
Molecular Medicine Reports.2013; 7(2): 485. CrossRef
A genetic association study between growth differentiation factor 5 (GDF 5) polymorphism and knee osteoarthritis in Thai population
Tulyapruek Tawonsawatruk, Theeraroj Changthong, Sarinee Pingsuthiwong, Objoon Trachoo, Thanyachai Sura, Wiwat Wajanavisit
Journal of Orthopaedic Surgery and Research.2011; 6(1): 47. CrossRef

Expression of Matrix Metalloproteinase (MMP)-1, MMP-3 Nitrotyrosine and Apoptosis in Articular Cartilage of Human Osteoarthritis.: So Young Jin, Seong Su Kang, Dong Wha Lee, Soo Jae Yim, Yeo Hon Yun, Byung Ill Lee; Korean J Pathol. 2001;35(4):319-329.

1,734 View
16 Download

Abstract PDF: BACKGROUND
Matrix metalloproteinase (MMP)-1 and 3 are the most important degradating enzymes of the chondroid matrix. Chondrocytes may undergo apoptosis under various stimuli including nitric oxide (NO). We studied the expression rate and zone of MMP-1, MMP-3, nitrotyrosine, a marker of NO release, and apoptosis in the articular cartilage of human osteoarthritis.
METHODS
To investigate the role of nitrotyrosine and apoptosis in the degradation of the chondroid matrix in human osteoarthritis, immunohistochemistry was done for MMP-1, MMP-3, and nitrotyrosine; and the terminal deoxynucleotidyl transferase mediated nick end labeling (TUNEL) method was performed for apoptosis using a total of 93 articular cartilages from 12 femoral heads and 17 knees obtained from total joint arthroplasty and 7 normal articular cartilages. RESULTS: In the normal control group, the expression rates for MMP-1, MMP-3, nitrotyrosine, and apoptosis were very low; and their expression zones were confined to the superficial layer of the articular cartilage. Their expression rates were low in the early stage of osteoarthritis and were moderate to high in the late stage (P<0.05). Their expression zones were confined to the superficial layer of the articular cartilage in the early stage of osteoarthritis and were expressed throughout the whole layer in the late stage and those of MMP-3 and nitrotyrosine were statistically significant (P<0.05). Their expression rates and zones were significantly correlated with the grade of osteoarthritis (P<0.05). Conclusion : The expression rate and zone of apoptosis and nitrotyrosine correlated well with those of MMP-1 and MMP-3. Therefore, NO and apoptosis may be related to the progression of human osteoarthritis.

First
Prev
Page of 1
Next
Last

Search