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- Upregulated Neuro-oncological Ventral Antigen 1 (NOVA1) Expression Is Specific to Mature and Immature T- and NK-Cell Lymphomas
- Eun Kyung Kim, Sun Och Yoon, Soo Hee Kim, Woo Ick Yang, Yoon Ah Cho, Soo Jeong Kim
- J Pathol Transl Med. 2016;50(2):104-112. Published online February 29, 2016
- DOI: https://doi.org/10.4132/jptm.2016.02.08
- 8,807 View
- 68 Download
- 14 Web of Science
- 13 Crossref
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Abstract
PDF - Background
Recent studies have revealed that the splicing factor neuro-oncological ventral antigen 1 (NOVA1) is enriched in fibroblasts and accumulated T cells of tertiary lymphoid structures. In the present study, we investigated NOVA1 expression in various subtypes of mature and immature T- and natural killer (NK)-cell lymphomas as well as in various B-cell lymphoma subtypes. Methods: NOVA1 immunoexpression was evaluated in hyperplastic palatine tonsils (n = 20), T- and NK-cell lymphomas (n = 177), diffuse large B-cell lymphomas (n = 151), and other types of B cell lymphomas (n = 31). Nuclear staining intensity and percentage of positive tumor cells were graded. NOVA1 mRNA expression was analyzed in various lymphoma cell lines. Results: Tumor cells of T- and NK-cell lymphomas showed higher expression levels of NOVA1 than did normal paracortical T cells, and 56.5% of T- and NK-cell lymphoma cases showed diffuse and strong expression. The NOVA1 expression level varied according to the subtype; it was higher in angioimmunoblastic T-cell lymphoma, anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL), and T lymphoblastic leukemia/lymphoma (T-LBL), but it was lower in ALK-positive ALCL. In almost all B-cell lymphomas, NOVA1 expression was very low or negative. NOVA1 mRNA was also expressed in Jurkat, a T-LBL cell line. Conclusions: The present findings suggest that NOVA1 upregulation may be involved in certain subtypes of T- and NK-cell lymphomas, but not in B-cell lymphomas. Upregulated NOVA1 expression seems to be a specific biological feature of activated T cells such as T- and NK-cell lymphomas. -
Citations
Citations to this article as recorded by
- Intraoperative pathologic diagnosis of central nervous system lymphomas: A comparison of frozen and permanent section diagnoses, and the significance of preoperative imaging
Aslı Kahraman, Fikret Dirilenoğlu, İsmail Güzeliş, Kenan Çetinoğlu
Annals of Diagnostic Pathology.2024; 69: 152246. CrossRef - NOVA1 acts on Impact to regulate hypothalamic function and translation in inhibitory neurons
Yoko Tajima, Keiichi Ito, Yuan Yuan, Mayu O. Frank, Yuhki Saito, Robert B. Darnell
Cell Reports.2023; 42(2): 112050. CrossRef - MicroRNA miR-27a-3p accelerates cardiac hypertrophy by targeting neuro-oncological ventral antigen 1
Dongyun Li, Mingzhi Shen, Xinxin Deng, Yongyi Bai
Bioengineered.2022; 13(4): 8982. CrossRef - NOVA1 promotes NSCLC proliferation and invasion by activating Wnt/β-catenin signaling
Lianyue Qu, Yulong Tian, Fan Wang, Zixuan Li
BMC Cancer.2022;[Epub] CrossRef - Identification of the Functions and Prognostic Values of RNA Binding Proteins in Bladder Cancer
Yue Wu, Zheng Liu, Xian Wei, Huan Feng, Bintao Hu, Bo Liu, Yang Luan, Yajun Ruan, Xiaming Liu, Zhuo Liu, Shaogang Wang, Jihong Liu, Tao Wang
Frontiers in Genetics.2021;[Epub] CrossRef - Nervous system and gastric cancer
Ke Wang, Xin-hui Zhao, Jun Liu, Rui Zhang, Ji-peng Li
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2020; 1873(1): 188313. CrossRef - The RNA-binding protein RBM47 inhibits non-small cell lung carcinoma metastasis through modulation of AXIN1 mRNA stability and Wnt/β-catentin signaling
Di-jian Shen, You-hua Jiang, Jian-qiang Li, Li-wei Xu, Kai-yi Tao
Surgical Oncology.2020; 34: 31. CrossRef - Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1
Junfen Xu, Habin Liu, Yanqin Yang, Xiaohong Wang, Poching Liu, Yang Li, Craig Meyers, Nilam Sanjib Banerjee, Hsu-Kun Wang, Maggie Cam, Weiguo Lu, Louise T. Chow, Xing Xie, Jun Zhu, Zhi-Ming Zheng, Xiang-Jin Meng, James Pipas, Xuefeng Liu, Lucia Pirisi-cre
mBio.2019;[Epub] CrossRef - NOVA1 induction by inflammation and NOVA1 suppression by epigenetic regulation in head and neck squamous cell carcinoma
Eun Kyung Kim, Yoon Ah Cho, Mi-kyoung Seo, Hyunmi Ryu, Byoung Chul Cho, Yoon Woo Koh, Sun Och Yoon
Scientific Reports.2019;[Epub] CrossRef - The RNA binding protein neuro‐oncological ventral antigen 1 (NOVA1) regulates IL-6 mRNA stability to enhance JAK2-STAT3 signaling in CRC
Yong-gang Hong, Guo-shu Xu, Guan-yu Yu, Ji-dian Zhou, Qi-zhi Liu, Jun-sheng Ni, Hong-li Yan, Wei Zhang, Li-qiang Hao
Surgical Oncology.2019; 31: 67. CrossRef - NOVA1 acts as an oncogene in melanoma via regulating FOXO3a expression
Xin Yu, Heyi Zheng, Matthew T.V. Chan, William K.K. Wu
Journal of Cellular and Molecular Medicine.2018; 22(5): 2622. CrossRef - Neuro‐oncological ventral antigen 1 (NOVA1): Implications in neurological diseases and cancers
Yu Xin, Zheng Li, Heyi Zheng, Jeffery Ho, Matthew T. V. Chan, William K. K. Wu
Cell Proliferation.2017;[Epub] CrossRef - New developments in the pathology of malignant lymphoma. A review of the literature published from January–April 2016
J. Han van Krieken
Journal of Hematopathology.2016; 9(2): 73. CrossRef
- Intraoperative pathologic diagnosis of central nervous system lymphomas: A comparison of frozen and permanent section diagnoses, and the significance of preoperative imaging
- Genotype of Epstein-Barr Virus and Comparative Genomic Hybridization Analysis of NK/T Cell Lymphoma.
- Keying Eun Choi, Young Hyeh Ko
- Korean J Pathol. 2000;34(8):541-549.
- 1,417 View
- 11 Download
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Abstract
PDF
- NK/T cell lymphoma is a distinct clinicopathologic entity which is more prevalent in Asia than in America and Europe and is highly associated with Epstein-Barr virus (EBV) infection. Although the clinicopathologic features of the tumor have been clearly defined, genetic changes and roles of virus associated with the development and progression of tumor have not been well studied. In this study, we carried out polymerase chain reaction (PCR) for EBNA-3B, EBNA-3C, and LMP-1 30 bp deletion to investigate EBV subtype and variants in tumor tissue and performed comparative genomic hybridization (CGH) to screen chromosomal imbalances using frozen tissues from 7 patients with nasal-type NK/T cell lymphoma and 1 patient with blastic NK cell lymphoma. Of 6 cases infected with EBV, there were EBV type 1 in six, LMP-1 30 bp deletion variant in four, and LMP-1 40 bp deletion variant in one. Frequent chromosomal imbalances included deletions at 1p31-pter (4), 12q23-q24 (3), and 17p (4), and gains at 2q (5), 10q (3), and 13q34-qter (4). Blastic NK cell lymphoma displayed deletions of 9q, 7q, and 6q, similar to that of nasal-type NK/T-cell lymphoma. With these results, we assumed that candidate genes in these imbalanced chromosomal loci would provide the clue for further molecular studies to identify putative tumor suppressor genes or proto-oncogenes associated with pathogenesis of this neoplasm.
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