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Original Articles
- Comparison of Squamous Cell Carcinoma of the Tongue between Young and Old Patients
- Gyuheon Choi, Joon Seon Song, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Jong-Lyel Roh, Bu-Kyu Lee, Kyung-Ja Cho
- J Pathol Transl Med. 2019;53(6):369-377. Published online October 11, 2019
- DOI: https://doi.org/10.4132/jptm.2019.09.16
- 5,693 View
- 177 Download
- 6 Web of Science
- 9 Crossref
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Abstract
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Supplementary Material - Background
The worldwide incidence of squamous cell carcinoma of the tongue (SCCOT) in young patients has been increasing. We investigated clinicopathologic features of this unique population and compared them with those of SCCOT in the elderly to delineate its pathogenesis.
Methods
We compared clinicopathological parameters between patients under and over 45 years old. Immunohistochemical assays of estrogen receptor, progesterone receptor, androgen receptor, p53, p16, mdm2, cyclin D1, and glutathione S-transferase P1 were also compared between them.
Results
Among 189 cases, 51 patients (27.0%) were under 45 years of age. A higher proportion of women was seen in the young group, but was not statistically significant. Smoking and drinking behaviors between age groups were similar. Histopathological and immunohistochemical analysis showed no significant difference by age and sex other than higher histologic grades observed in young patients.
Conclusions
SCCOT in young adults has similar clinicopathological features to that in the elderly, suggesting that both progress via similar pathogenetic pathways. -
Citations
Citations to this article as recorded by
- High Failure Rates in Young Nonsmoker Nondrinkers With Squamous Cell Carcinoma of the Oral Tongue
Brianna M. Jones, Dillan F. Villavisanis, Eric J. Lehrer, Daniel R. Dickstein, Kunal K. Sindhu, Krzysztof J. Misiukiewicz, Marshall Posner, Jerry T. Liu, Vishal Gupta, Sonam Sharma, Scott A. Roof, Marita Teng, Eric M. Genden, Richard L. Bakst
The Laryngoscope.2023; 133(5): 1110. CrossRef - Characteristics of oral squamous cell carcinoma focusing on cases unaffected by smoking and drinking: A multicenter retrospective study
Hiroyuki Harada, Masahiro Kikuchi, Ryo Asato, Kiyomi Hamaguchi, Hisanobu Tamaki, Masanobu Mizuta, Ryusuke Hori, Tsuyoshi Kojima, Keigo Honda, Takashi Tsujimura, Yohei Kumabe, Kazuyuki Ichimaru, Yoshiharu Kitani, Koji Ushiro, Morimasa Kitamura, Shogo Shino
Head & Neck.2023; 45(7): 1812. CrossRef - Genetic characteristics of advanced oral tongue squamous cell carcinoma in young patients
Sehui Kim, Chung Lee, Hyangmi Kim, Sun Och Yoon
Oral Oncology.2023; 144: 106466. CrossRef - Oral Squamous Cell Carcinoma Frequency in Young Patients from Referral Centers Around the World
Rafael Ferreira e Costa, Marina Luiza Baião Leão, Maria Sissa Pereira Sant’Ana, Ricardo Alves Mesquita, Ricardo Santiago Gomez, Alan Roger Santos-Silva, Syed Ali Khurram, Artysha Tailor, Ciska-Mari Schouwstra, Liam Robinson, Willie F. P. van Heerden, Rami
Head and Neck Pathology.2022; 16(3): 755. CrossRef - Early-onset oral cancer as a clinical entity: aetiology and pathogenesis
E.S. Kolegova, M.R. Patysheva, I.V. Larionova, I.K. Fedorova, D.E. Kulbakin, E.L. Choinzonov, E.V. Denisov
International Journal of Oral and Maxillofacial Surgery.2022; 51(12): 1497. CrossRef - The effect of age on the clinicopathological features of oral squamous cell carcinoma
Alaa S Saeed, Bashar H Abdullah
Journal of Baghdad College of Dentistry.2022; 34(1): 25. CrossRef - Survival Outcomes in Oral Tongue Cancer: A Mono-Institutional Experience Focusing on Age
Mohssen Ansarin, Rita De Berardinis, Federica Corso, Gioacchino Giugliano, Roberto Bruschini, Luigi De Benedetto, Stefano Zorzi, Fausto Maffini, Fabio Sovardi, Carolina Pigni, Donatella Scaglione, Daniela Alterio, Maria Cossu Rocca, Susanna Chiocca, Sara
Frontiers in Oncology.2021;[Epub] CrossRef - A meta-analysis of oral squamous cell carcinoma in young adults with a comparison to the older group patients (2014–2019)
Khadijah Mohideen, C Krithika, Nadeem Jeddy, Thayumanavan Balakrishnan, R Bharathi, SLeena Sankari
Contemporary Clinical Dentistry.2021; 12(3): 213. CrossRef - Modern perspectives of oral squamous cell carcinoma
A.A. Ivina
Arkhiv patologii.2020; 82(3): 55. CrossRef
- High Failure Rates in Young Nonsmoker Nondrinkers With Squamous Cell Carcinoma of the Oral Tongue
- Metastatic Carcinomas to the Oral Cavity and Oropharynx
- Su-Jin Shin, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Sung Bae Kim, Sang-wook Lee, Kyung-Ja Cho
- Korean J Pathol. 2012;46(3):266-271. Published online June 22, 2012
- DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.266
- 8,333 View
- 66 Download
- 17 Crossref
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Abstract
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Background Metastases to the oral/oropharynx are very rare and their diagnosis is challenging.
Methods We reviewed pathologic data for malignant tumors of the oral/oropharynx that were diagnosed at the Asan Medical Center, Seoul, Korea from 1995 until 2010.
Results Twenty-nine cases of oral/oropharyngeal metastases were retrieved, comprising 2.0% of 1,445 malignancies. The most common primary sites were the liver and lung, followed by the stomach, colon, breast, prostate, and kidney. The gingiva was the most common metastatic site, followed by the tonsil/pillar, mandible, tongue, tongue base, palate mucosa, mouth floor, and buccal mucosa. Intervals between detection of primary tumors and metastases were variable, from -1 month to 104 months. Ten patients with lung (7 cases), liver, stomach, and kidney carcinomas manifested with oral/oropharyngeal metastases as the first sign of systemic metastases. The majority of patients had died within one year of the onset of an oral/oropharyngeal metastasis, but exceptionally long-lived cases were also present. The survival periods of patients with lung cancers were longer than those of patients with non-pulmonary tumors.
Conclusions An awareness of the incidence, common primary sites, metastatic subsites, and metastatic courses or patterns of oral/oropharyngeal metastases is helpful in the diagnosis of metastatic carcinomas.
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Citations
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Seiji Baba, Kyoko Ishimaru, Eiji Ito, Saki Goto, Keizo Kato, Yoichi Yamada
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2024; 36(1): 95. CrossRef - Mandibular metastasis of follicular thyroid carcinoma: A case report along with the concise review of literature
MK Jawanda, R Narula, S Gupta, P Gupta
Journal of Oral and Maxillofacial Pathology.2022; 26(1): 133. CrossRef - Gingival metastasis from primary hepatocellular carcinoma: a case report
Yuan Huang, Yanqiu Bao, Dongyuan Xu, Lan Liu
Journal of International Medical Research.2022; 50(7): 030006052211134. CrossRef - Lung carcinoma presenting as bilateral metastases in the mandibular gingivae: a case report and literature review
Nusaybah Elsherif, Predrag Jeremic, Tim Blackburn
Dental Update.2021; 48(10): 846. CrossRef - Recurrent clear cell carcinoma of the tongue base with high grade transformation in a pregnant patient
Emad M. Al Haj Ali, Ahmed M. Ibrahim, Tamer A. Ghanem, Christian E. Keller
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2020; 32(2): 104. CrossRef - Primary Lingual Colonic-Type Adenocarcinoma: A Rare and Emerging Distinct Entity!
Stephen M. Smith, Matthew Old, O. Hans Iwenofu
Head and Neck Pathology.2017; 11(2): 234. CrossRef - Rare Gingival Metastasis by Hepatocellular Carcinoma
Li-Jun Xue, Xiao-Bei Mao, Jian Geng, Ya-Nan Chen, Qian Wang, Xiao-Yuan Chu
Case Reports in Medicine.2017; 2017: 1. CrossRef - Hepatoid adenocarcinoma of the lung metastasizing to the tonsil
Luca Valle, Joel Thomas, Chul Kim, Eva Szabo, G. Thomas Brown, Deborah Citrin, Arun Rajan
Molecular and Clinical Oncology.2017; 6(5): 705. CrossRef - Epulis-Like Presentation of Gingival Renal Cancer Metastasis
Gianfilippo Nifosì, Hubert Bressand, Antonio Fabrizio Nifosì, Lorenzo Nifosì, Pierre Damseaux
Case Reports in Oncology.2017; 10(2): 758. CrossRef - A Case of Oral Metastasis From Hepatocellular Carcinoma Displayed on 18F-FDG PET/CT Imaging
Lei Jiang, Taoying Gu, Fang Liu, Lijuan Luan, Hongcheng Shi
Clinical Nuclear Medicine.2016; 41(1): 72. CrossRef - A case of renal cell carcinoma diagnosed in association with a palatal mucosa mass
Masaharu NOI, Yoshizou TSUDA, Shota SAITO, Takeshi ADACHI, Tomoki HIGO, Gaku YAMAMOTO
Japanese Journal of Oral and Maxillofacial Surgery.2016; 62(2): 62. CrossRef - Unusual Presentation of an Adenocarcinoma of the Lung Metastasizing to the Mandible, Including Molecular Analysis and a Review of the Literature
Sibel Elif Gultekin, Burcu Senguven, Ipek Isik Gonul, Begum Okur, Reinhard Buettner
Journal of Oral and Maxillofacial Surgery.2016; 74(10): 2007.e1. CrossRef - A Case of Hepatocellular Carcinoma Presenting as a Gingival Mass
Min Jung Kwon, Soo Hyung Ryu, Soo Yeon Jo, Chul Hoon Kwak, Won Jae Yoon, Jeong Seop Moon, Hye Kyung Lee
The Korean Journal of Gastroenterology.2016; 68(6): 321. CrossRef - Mandibular metastasis of cholangiocarcinoma: A case report
Tae Min You, Kee-Deog Kim, Ho-Gul Jeong, Wonse Park
Imaging Science in Dentistry.2015; 45(4): 247. CrossRef - Oral Floor and Gingival Metastasis of Cholangiocarcinoma: A Case Report and Review of the Literature
Yukihiro Nakanishi, Bo Xu, Charles LeVea
Case Reports in Pathology.2014; 2014: 1. CrossRef - Primary Squamous Cell Carcinoma of Lung Leading to Metastatic Jaw Tumor
Chintamaneni Raja Lakshmi, M. Sudhakara Rao, Sujana Mulk Bhavana, Sivan Sathish
Case Reports in Pulmonology.2014; 2014: 1. CrossRef - A Case of Gingival Metastasis from Rectal Cancer in Which Immunohistochemistry and PET-CT Were Useful for the Diagnostic Procedure
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Case Reports in Oncology.2014; 7(1): 246. CrossRef
- Metastasis of leiomyosarcoma to the sublingual region
Case Report
- Primary Mucosal Desmoplastic Melanoma of Gingiva: A Case Report.
- Gawon Choi, Jeong Won Kim, Soon Yuhl Nam, Kyung Ja Cho
- Korean J Pathol. 2006;40(6):456-460.
- 1,523 View
- 14 Download
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Abstract
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- Desmoplastic melanoma (DM) is a rare malignant melanoma variant. Although DM mainly affects the skin chronically exposed to the sun, a small number of mucosal DM have been reported. Primary mucosal DM is difficult to diagnose because of its rarity and atypical histopathologic features. Here, we report a case of DM in a 52 year-old female who presented with a right cervical mass and upper gingival pigmentation. A CT scan revealed an ill-defined infiltrative mass 2 cm in size under the pigmented mucosa. She subsequently underwent a partial maxillectomy with neck dissection. Gross examination revealed that the mass exhibited a grayish white fibrotic cut surface and that the maxillary bone had been destroyed. Microscopically, the main mass was composed of cigar-shaped or wavy spindle cells with desmoplastic stroma under the melanoma in situ. The diagnosis of DM was confirmed immunohistochemically with S100 protein positivity and HMB45 negativity. The patient has survived for 29 months after the operation with a presumed metastatic focus.
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