Meningioma is the most common primary intracranial tumor in adults. The grading of meningioma is based on World Health Organization criteria, which rely on histopathological features alone. This grading system is unable to conclusively predict the clinical behavior of these tumors (i.e., recurrence or prognosis in benign or atypical grades). Advances in molecular techniques over the last decade that include genomic and epigenomic data associated with meningiomas have been used to identify genetic biomarkers that can predict tumor behavior. This review summarizes the molecular characteristics of meningioma using genetic and epigenetic biomarkers. Molecular alterations that can predict meningioma behavior may be integrated into the upcoming World Health Organization grading system.
Citations
Citations to this article as recorded by
DNA methylation profiling of meningiomas highlights clinically distinct molecular subgroups Jyotsna Singh, Ravi Sharma, Nidhi Shukla, Priya Narwal, Amit Katiyar, Swati Mahajan, Saumya Sahu, Ajay Garg, Mehar C. Sharma, Ashish Suri, Chitra sarkar, Vaishali Suri Journal of Neuro-Oncology.2023; 161(2): 339. CrossRef
Spinal meningiomas, from biology to management - A literature review Nicolas Serratrice, Imène Lameche, Christian Attieh, Moussa A Chalah, Joe Faddoul, Bilal Tarabay, Rabih Bou-Nassif, Youssef Ali, Joseph G Mattar, François Nataf, Samar S Ayache, Georges N Abi Lahoud Frontiers in Oncology.2023;[Epub] CrossRef
Somatic mutation landscape in a cohort of meningiomas that have undergone grade progression Sarah A Cain, Bernard Pope, Stefano Mangiola, Theo Mantamadiotis, Katharine J Drummond BMC Cancer.2023;[Epub] CrossRef
Actualización sobre el meningioma: correlación clínico-radiológica y radio-patológica A. Navarro-Ballester, M. Aleixandre-Barrachina, S.F. Marco-Doménech Radiología.2023;[Epub] CrossRef
The integrated multiomic diagnosis of sporadic meningiomas: a review of its clinical implications Stephanie M. Robert, Shaurey Vetsa, Arushii Nadar, Sagar Vasandani, Mark W. Youngblood, Evan Gorelick, Lan Jin, Neelan Marianayagam, E Zeynep Erson-Omay, Murat Günel, Jennifer Moliterno Journal of Neuro-Oncology.2022; 156(2): 205. CrossRef
Clinical presentation, diagnostic findings and outcome of dogs undergoing surgical resection for intracranial meningioma: 101 dogs Alexander K. Forward, Holger Andreas Volk, Giunio Bruto Cherubini, Tom Harcourt-Brown, Ioannis N. Plessas, Laurent Garosi, Steven De Decker BMC Veterinary Research.2022;[Epub] CrossRef
Sphenoid wing meningiomas: peritumoral brain edema as a prognostic factor in surgical outcome Abdalrahman Nassar, Volodymyr Smolanka, Andriy Smolanka, Dipak Chaulagain, Oleg Devinyak Neurosurgical Review.2022; 45(4): 2951. CrossRef
Potential Molecular Mechanisms of Recurrent and Progressive Meningiomas: A Review of the Latest Literature Wenjie Peng, Pei Wu, Minghao Yuan, Bo Yuan, Lian Zhu, Jiesong Zhou, Qian Li Frontiers in Oncology.2022;[Epub] CrossRef
Case Report: Upper Thoracic Purely Extradural Spinal Meningioma With Nerve Root Attachment: A Case Report and Literature Review Zhao-Lin Wang, Jian-Hui Mou, Dong Sun, Peng Liu Frontiers in Surgery.2022;[Epub] CrossRef
Molecular diagnosis and treatment of meningiomas: an expert consensus (2022) Jiaojiao Deng, Lingyang Hua, Liuguan Bian, Hong Chen, Ligang Chen, Hongwei Cheng, Changwu Dou, Dangmurenjiapu Geng, Tao Hong, Hongming Ji, Yugang Jiang, Qing Lan, Gang Li, Zhixiong Liu, Songtao Qi, Yan Qu, Songsheng Shi, Xiaochuan Sun, Haijun Wang, Yongpi Chinese Medical Journal.2022; 135(16): 1894. CrossRef
The Prognostic Value of Methylation Signatures and NF2 Mutations in Atypical Meningiomas Rahmina Meta, Henning B. Boldt, Bjarne W. Kristensen, Felix Sahm, Wenche Sjursen, Sverre H. Torp Cancers.2021; 13(6): 1262. CrossRef
Neurofibromatosis Type 2 (NF2) and the Implications for Vestibular Schwannoma and Meningioma Pathogenesis Suha Bachir, Sanjit Shah, Scott Shapiro, Abigail Koehler, Abdelkader Mahammedi, Ravi N. Samy, Mario Zuccarello, Elizabeth Schorry, Soma Sengupta International Journal of Molecular Sciences.2021; 22(2): 690. CrossRef
Meningioma: A Review of Epidemiology, Pathology, Diagnosis, Treatment, and Future Directions Christian Ogasawara, Brandon D. Philbrick, D. Cory Adamson Biomedicines.2021; 9(3): 319. CrossRef
The substantial loss of H3K27me3 can stratify risk in grade 2, but not in grade 3 meningioma Minsun Jung, Seong-Ik Kim, Ka Young Lim, Jeongmo Bae, Chul-Kee Park, Seung Hong Choi, Sung-Hye Park, Jae-Kyung Won Human Pathology.2021; 115: 96. CrossRef
Papillary Meningioma: Case Presentation with Emphasis on Surgical and Medical Therapy of a Rare Variant of Meningioma Gerardo Cazzato, Valeria Internò, Antonietta Cimmino, Raffaella Messina, Marco Tucci, Teresa Lettini, Leonardo Resta, Giuseppe Ingravallo Diseases.2021; 9(3): 63. CrossRef
An Overview of Managements in Meningiomas Lianhua Zhao, Wei Zhao, Yanwei Hou, Cuixia Wen, Jing Wang, Pei Wu, Zaiyu Guo Frontiers in Oncology.2020;[Epub] CrossRef
Multi-Omics Analysis in Initiation and Progression of Meningiomas: From Pathogenesis to Diagnosis Jiachen Liu, Congcong Xia, Gaiqing Wang Frontiers in Oncology.2020;[Epub] CrossRef
Molecular Mechanism and Approach in Progression of Meningioma Zhiwei Shao, Lihong Liu, Yanghao Zheng, Sheng Tu, Yuanbo Pan, Sheng Yan, Qichun Wei, Anwen Shao, Jianmin Zhang Frontiers in Oncology.2020;[Epub] CrossRef
Multiple meningiomas: does quantity matter? a population-based survival analysis with underlined age and sex differences Andres Ramos-Fresnedo, Ricardo A. Domingo, Tito Vivas-Buitrago, Larry Lundy, Daniel M. Trifiletti, Mark E. Jentoft, Amit B. Desai, Alfredo Quiñones-Hinojosa Journal of Neuro-Oncology.2020; 149(3): 413. CrossRef
Meningioma: A Review of Clinicopathological and Molecular Aspects Kristin Huntoon, Angus Martin Shaw Toland, Sonika Dahiya Frontiers in Oncology.2020;[Epub] CrossRef
Neues zur Einteilung und Therapie von Meningeomen Corinna Seliger, Wolfgang Wick Neurologie up2date.2020; 3(04): 343. CrossRef
Hye Seung Lee, Woo Ho Kim, Yoonjin Kwak, Jiwon Koh, Jeong Mo Bae, Kyoung-Mee Kim, Mee Soo Chang, Hye Seung Han, Joon Mee Kim, Hwal Woong Kim, Hee Kyung Chang, Young Hee Choi, Ji Y. Park, Mi Jin Gu, Min Jin Lhee, Jung Yeon Kim, Hee Sung Kim, Mee-Yon Cho
J Pathol Transl Med. 2017;51(2):103-121. Published online February 19, 2017
With recent advances in molecular diagnostic methods and targeted cancer therapies, several molecular tests have been recommended for gastric cancer (GC) and colorectal cancer (CRC). Microsatellite instability analysis of gastrointestinal cancers is performed to screen for Lynch syndrome, predict favorable prognosis, and screen patients for immunotherapy. The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor has been approved in metastatic CRCs with wildtype RAS (KRAS and NRAS exon 2–4). A BRAF mutation is required for predicting poor prognosis. Additionally, amplification of human epidermal growth factor receptor 2 (HER2) and MET is also associated with resistance to EGFR inhibitor in metastatic CRC patients. The BRAF V600E mutation is found in sporadic microsatellite unstable CRCs, and thus is helpful for ruling out Lynch syndrome. In addition, the KRAS mutation is a prognostic biomarker and the PIK3CA mutation is a molecular biomarker predicting response to phosphoinositide 3-kinase/AKT/mammalian target of rapamycin inhibitors and response to aspirin therapy in CRC patients. Additionally, HER2 testing should be performed in all recurrent or metastatic GCs. If the results of HER2 immunohistochemistry are equivocal, HER2 silver or fluorescence in situ hybridization testing are essential for confirmative determination of HER2 status. Epstein-Barr virus–positive GCs have distinct characteristics, including heavy lymphoid stroma, hypermethylation phenotype, and high expression of immune modulators. Recent advances in next-generation sequencing technologies enable us to examine various genetic alterations using a single test. Pathologists play a crucial role in ensuring reliable molecular testing and they should also take an integral role between molecular laboratories and clinicians.
Citations
Citations to this article as recorded by
A Standardized Pathology Report for Gastric Cancer: 2nd Edition Young Soo Park, Myeong-Cherl Kook, Baek-hui Kim, Hye Seung Lee, Dong-Wook Kang, Mi-Jin Gu, Ok Ran Shin, Younghee Choi, Wonae Lee, Hyunki Kim, In Hye Song, Kyoung-Mee Kim, Hee Sung Kim, Guhyun Kang, Do Youn Park, So-Young Jin, Joon Mee Kim, Yoon Jung Choi, Journal of Gastric Cancer.2023; 23(1): 107. CrossRef
A standardized pathology report for gastric cancer: 2nd edition Young Soo Park, Myeong-Cherl Kook, Baek-hui Kim, Hye Seung Lee, Dong-Wook Kang, Mi-Jin Gu, Ok Ran Shin, Younghee Choi, Wonae Lee, Hyunki Kim, In Hye Song, Kyoung-Mee Kim, Hee Sung Kim, Guhyun Kang, Do Youn Park, So-Young Jin, Joon Mee Kim, Yoon Jung Choi, Journal of Pathology and Translational Medicine.2023; 57(1): 1. CrossRef
Korean Practice Guidelines for Gastric Cancer 2022: An Evidence-based, Multidisciplinary Approach Tae-Han Kim, In-Ho Kim, Seung Joo Kang, Miyoung Choi, Baek-Hui Kim, Bang Wool Eom, Bum Jun Kim, Byung-Hoon Min, Chang In Choi, Cheol Min Shin, Chung Hyun Tae, Chung sik Gong, Dong Jin Kim, Arthur Eung-Hyuck Cho, Eun Jeong Gong, Geum Jong Song, Hyeon-Su Im Journal of Gastric Cancer.2023; 23(1): 3. CrossRef
Influence of location-dependent sex difference on PD-L1, MMR/MSI, and EGFR in colorectal carcinogenesis Jina Choi, Nayoung Kim, Ryoung Hee Nam, Jin Won Kim, Chin-Hee Song, Hee Young Na, Gyeong Hoon Kang, Alvaro Galli PLOS ONE.2023; 18(2): e0282017. CrossRef
Exosomal circ_0001190 Regulates the Progression of Gastric Cancer via miR-586/SOSTDC1 Axis Chao Liu, Jing Yang, Fengchi Zhu, Zhiying Zhao, Lixue Gao Biochemical Genetics.2022; 60(6): 1895. CrossRef
Optimization of pre‐analytical and analytical steps for
DNA
and
RNA
analysis of fresh cytology samples
Ana Dolinar, Gašper Grubelnik, Irena Srebotnik‐Kirbiš, Margareta Strojan Fležar, Margareta Žlajpah Cancer Medicine.2022; 11(21): 4021. CrossRef
Connexin 43 upregulation by dioscin‐inhibited gastric cancer metastasis by suppressing
PI3K
/Akt pathway
Yu Kou, Rentao Zhu, Qidi Sun, Zhuoqun Li, Xuan Feng, Hairong Xu Food Science & Nutrition.2022;[Epub] CrossRef
Molecular Pathology of Gastric Cancer Moonsik Kim, An Na Seo Journal of Gastric Cancer.2022; 22(4): 264. CrossRef
Case report: Undifferentiated sarcoma with multiple tumors involved in Lynch syndrome: Unexpected favorable outcome to sintilimab combined with chemotherapy Jiaying Liu, Xiaona Chang, Guixiang Xiao, Jingmin Zhong, Bo Huang, Jiwei Zhang, Beibei Gao, Gang Peng, Xiu Nie Frontiers in Oncology.2022;[Epub] CrossRef
The SUMO E3 ligase CBX4 is identified as a poor prognostic marker of gastric cancer through multipronged OMIC analyses Yi Pan, Qingshang Li, Zhijun Cao, Shuliang Zhao Genes & Diseases.2021; 8(6): 827. CrossRef
Worldwide variation in lynch syndrome screening: case for universal screening in low colorectal cancer prevalence areas George Kunnackal John, Vipin Das Villgran, Christine Caufield-Noll, Francis Giardiello Familial Cancer.2021; 20(2): 145. CrossRef
Tamoxifen Downregulates the Expression of Notch1 and DLL1 Genes in MKN-45 Gastric Cancer Cells Faranak Khanipouyani, Hassan Akrami Journal of Gastrointestinal Cancer.2021; 52(3): 922. CrossRef
Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis Saeranee Siriphak, Ravinnipa Chanakankun, Tanakorn Proungvitaya, Sittiruk Roytrakul, Doungdean Tummanatsakun, Wunchana Seubwai, Molin Wongwattanakul, Siriporn Proungvitaya Molecules.2021; 26(11): 3105. CrossRef
ISH-based HER2 diagnostics Josef Rüschoff, Iris Nagelmeier, Bharat Jasani, Oliver Stoss Der Pathologe.2021; 42(S1): 62. CrossRef
Identification and Analysis of Key Genes Driving Gastric Cancer Through Bioinformatics Zhao Liu, Shihai Liu, Jing Guo, Libin Sun, Shasha Wang, Yixuan Wang, Wensheng Qiu, Jing Lv Genetic Testing and Molecular Biomarkers.2021; 25(1): 1. CrossRef
Microsatellite Instability in Colorectal Cancer Liquid Biopsy—Current Updates on Its Potential in Non-Invasive Detection, Prognosis and as a Predictive Marker Francis Yew Fu Tieng, Nadiah Abu, Learn-Han Lee, Nurul-Syakima Ab Mutalib Diagnostics.2021; 11(3): 544. CrossRef
Metformin attenuates synergic effect of diabetes mellitus and
Helicobacter pylori
infection on gastric cancer cells proliferation by suppressing PTEN expression
Huibin Lu, Xinwei Han, Jianzhuang Ren, Kewei Ren, Zongming Li, Quanhui Zhang Journal of Cellular and Molecular Medicine.2021; 25(10): 4534. CrossRef
Recent Advances in the Diagnosis, Staging, Treatment, and Prognosis of Advanced Gastric Cancer: A Literature Review Zhi-da Chen, Peng-fei Zhang, Hong-qing Xi, Bo Wei, Lin Chen, Yun Tang Frontiers in Medicine.2021;[Epub] CrossRef
Tumor immune response and immunotherapy in gastric cancer Yoonjin Kwak, An Na Seo, Hee Eun Lee, Hye Seung Lee Journal of Pathology and Translational Medicine.2020; 54(1): 20. CrossRef
Comparative analysis of HER2 copy number between plasma and tissue samples in gastric cancer using droplet digital PCR Boram Kim, Soo Kyung Nam, Soo Hyun Seo, Kyoung Un Park, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Woo Ho Kim, Hye Seung Lee Scientific Reports.2020;[Epub] CrossRef
Differential prognostic impact of CD8+ T cells based on human leucocyte antigen I and PD-L1 expression in microsatellite-unstable gastric cancer Yoonjin Kwak, Jiwon Koh, Yujun Park, Yun Ji Hong, Kyoung Un Park, Hyung-Ho Kim, Do Joong Park, Sang-Hoon Ahn, Woo Ho Kim, Hye Seung Lee British Journal of Cancer.2020; 122(9): 1399. CrossRef
High-Accuracy Determination of Microsatellite Instability Compatible with Liquid Biopsies Amanda Bortolini Silveira, François-Clément Bidard, Amélie Kasperek, Samia Melaabi, Marie-Laure Tanguy, Manuel Rodrigues, Guillaume Bataillon, Luc Cabel, Bruno Buecher, Jean-Yves Pierga, Charlotte Proudhon, Marc-Henri Stern Clinical Chemistry.2020; 66(4): 606. CrossRef
Chitosan: A compound for drug delivery system in gastric cancer-a review Rana Shafabakhsh, Bahman Yousefi, Zatollah Asemi, Banafsheh Nikfar, Mohammad Ali Mansournia, Jamal Hallajzadeh Carbohydrate Polymers.2020; 242: 116403. CrossRef
MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link with Novel Immunotherapy Maria Grazia Rodriquenz, Giandomenico Roviello, Alberto D’Angelo, Daniele Lavacchi, Franco Roviello, Karol Polom Journal of Clinical Medicine.2020; 9(5): 1427. CrossRef
Theoretical calculations of molecular descriptors for anticancer activities of 1, 2, 3-triazole-pyrimidine derivatives against gastric cancer cell line (MGC-803): DFT, QSAR and docking approaches Rhoda Oyeladun Oyewole, Abel Kolawole Oyebamiji, Banjo Semire Heliyon.2020; 6(5): e03926. CrossRef
Identification of a Clinical Cutoff Value for Multiplex KRASG12/G13 Mutation Detection in Colorectal Adenocarcinoma Patients Using Digital Droplet PCR, and Comparison with Sanger Sequencing and PNA Clamping Assay Kyung Ha Lee, Tae Hee Lee, Min Kyung Choi, In Sun Kwon, Go Eun Bae, Min-Kyung Yeo Journal of Clinical Medicine.2020; 9(7): 2283. CrossRef
PD-L1 Testing in Gastric Cancer by the Combined Positive Score of the 22C3 PharmDx and SP263 Assay with Clinically Relevant Cut-offs Yujun Park, Jiwon Koh, Hee Young Na, Yoonjin Kwak, Keun-Wook Lee, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Hye Seung Lee Cancer Research and Treatment.2020; 52(3): 661. CrossRef
Clinical and Molecular Assessment of Patients with Lynch Syndrome and Sarcomas Underpinning the Association with MSH2 Germline Pathogenic Variants Nathália de Angelis de Carvalho, Bianca Naomi Niitsuma, Vanessa Nascimento Kozak, Felipe D’almeida Costa, Mariana Petaccia de Macedo, Bruna Elisa Catin Kupper, Maria Letícia Gobo Silva, Maria Nirvana Formiga, Sahlua Miguel Volc, Samuel Aguiar Junior, Eden Cancers.2020; 12(7): 1848. CrossRef
Farnesoid X receptor antagonizes Wnt/β-catenin signaling in colorectal tumorigenesis Junhui Yu, Shan Li, Jing Guo, Zhengshui Xu, Jianbao Zheng, Xuejun Sun Cell Death & Disease.2020;[Epub] CrossRef
YAP promotes self-renewal of gastric cancer cells by inhibiting expression of L-PTGDS and PTGDR2 Qingli Bie, Xiaozhe Li, Shiqi Liu, Xiao Yang, Zhenwen Qian, Rou Zhao, Xiaobei Zhang, Bin Zhang International Journal of Clinical Oncology.2020; 25(12): 2055. CrossRef
ISH-basierte HER2-Diagnostik Josef Rüschoff, Iris Nagelmeier, Bharat Jasani, Oliver Stoss Der Pathologe.2020; 41(6): 606. CrossRef
Histone Deacetylase Inhibitor Trichostatin A Suppresses Cell Proliferation and Induces Apoptosis by Regulating the PI3K/AKT Signalling Pathway in Gastric Cancer Cells Xinli An, Zekun Wei, Botian Ran, Hao Tian, Hongyu Gu, Yan Liu, Hongjuan Cui, Shunqin Zhu Anti-Cancer Agents in Medicinal Chemistry.2020; 20(17): 2114. CrossRef
Role of Her-2 in Gastrointestinal Tumours beyond Gastric Cancer: A Tool for Precision Medicine Csongor G. Lengyel, Baker Habeeb, Shah Z. Khan, Khalid El Bairi, Sara C. Altuna, Sadaqat Hussain, Syed Ayub Mazher, Dario Trapani, Angelica Petrillo Gastrointestinal Disorders.2020; 3(1): 1. CrossRef
Next-generation Sequencing in the Management of Gastric and Esophageal Cancers Jill C. Rubinstein, Norman G. Nicolson, Nita Ahuja Surgical Clinics of North America.2019; 99(3): 511. CrossRef
Molecular profile in Paraguayan colorectal cancer patients, towards to a precision medicine strategy Tania Fleitas-Kanonnikoff, Carolina Martinez‐Ciarpaglini, Josefina Ayala, Cinthia Gauna, Rita Denis, Ita Yoffe, Silvia Sforza, María Teresa Martínez, Alicia Pomata, Maider Ibarrola‐Villava, Sipan Arevshatyan, Verónica Burriel, Diego Boscá, Oscar Pastor, A Cancer Medicine.2019; 8(6): 3120. CrossRef
Human epidermal growth factor receptor 2-positive digestive tumors Anna D. Wagner, Berna C. Özdemir, Josef Rüschoff Current Opinion in Oncology.2019; 31(4): 354. CrossRef
Assessing molecular subtypes of gastric cancer: microsatellite unstable and Epstein-Barr virus subtypes. Methods for detection and clinical and pathological implications Carolina Martinez-Ciarpaglini, Tania Fleitas-Kanonnikoff, Valentina Gambardella, Marta Llorca, Cristina Mongort, Regina Mengual, Gema Nieto, Lara Navarro, Marisol Huerta, Susana Rosello, Desamparados Roda, Noelia Tarazona, Samuel Navarro, Gloria Ribas, An ESMO Open.2019; 4(3): e000470. CrossRef
Current and future molecular diagnostics of gastric cancer Rachel Sin-Yu Choi, Wing Yin Xenia Lai, Lok Ting Claire Lee, Wing Lam Christa Wong, Xiao Meng Pei, Hin Fung Tsang, Joel Johnson Leung, William Chi Shing Cho, Man Kee Maggie Chu, Elaine Yue Ling Wong, Sze Chuen Cesar Wong Expert Review of Molecular Diagnostics.2019; 19(10): 863. CrossRef
Clinicopathologic significance of human leukocyte antigen class I expression in patients with stage II and III gastric cancer Yujun Park, Jiwon Koh, Yoonjin Kwak, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Woo Ho Kim, Hye Seung Lee Cancer Immunology, Immunotherapy.2019; 68(11): 1779. CrossRef
Development and Validation of an Easy-to-Implement, Practical Algorithm for the Identification of Molecular Subtypes of Gastric Cancer: Prognostic and Therapeutic Implications Jiwon Koh, Keun-Wook Lee, Soo Kyung Nam, An Na Seo, Ji-Won Kim, Jin Won Kim, Do Joong Park, Hyung-Ho Kim, Woo Ho Kim, Hye Seung Lee The Oncologist.2019; 24(12): e1321. CrossRef
Mechanisms and Therapy for Cancer Metastasis to the Brain Federica Franchino, Roberta Rudà, Riccardo Soffietti Frontiers in Oncology.2018;[Epub] CrossRef
Status of programmed death-ligand 1 expression in sarcomas Hyung Kyu Park, Mingi Kim, Minjung Sung, Seung Eun Lee, Yu Jin Kim, Yoon-La Choi Journal of Translational Medicine.2018;[Epub] CrossRef
Design and synthesis of near-infrared fluorescence-enhancement probes for the cancer-specific enzyme hNQO1 Changyu Zhang, Bei-Bei Zhai, Tao Peng, Zelin Zhong, Lianbin Xu, Qiang-Zhe Zhang, Lu-Yuan Li, Long Yi, Zhen Xi Dyes and Pigments.2017; 143: 245. CrossRef
Progress in the treatment of advanced gastric cancer Zheyu Song, Yuanyu Wu, Jiebing Yang, Dingquan Yang, Xuedong Fang Tumor Biology.2017; 39(7): 101042831771462. CrossRef
Pathologische Einteilung und Diagnostik des Ösophagus- und Magenkarzinoms S. Förster, A. Tannapfel Der Gastroenterologe.2017; 12(5): 394. CrossRef
NR4A1-induced increase in the sensitivity of a human gastric cancer line to TNFα-mediated apoptosis is associated with the inhibition of JNK/Parkin-dependent mitophagy Hongzhu Yan, Feng Xiao, Jue Zou, Chengmin Qiu, Weiwei Sun, Minmin Gu, Li Zhang International Journal of Oncology.2017;[Epub] CrossRef